Exploring high entropy alloys: A review on thermodynamic design and computational modeling strategies for advanced materials applications.

In the quest for materials that can withstand the rigors of modern engineering applications, high-entropy alloys (HEAs) have emerged as a frontier in material science owing to their unprecedented combination of properties. This review focuses on intricate thermodynamic and computational modeling to guide the design and optimization of HEAs. By dissecting the foundational "four core effects" intrinsic to HEAs-high entropy, sluggish diffusion, severe lattice distortion, and cocktail effect-we illuminate the path towards predictable and tailored material properties.

A Systematic Literature Review on the Global Status of Newborn Screening for Mucopolysaccharidosis II.

A systematic literature review was conducted to determine the global status of newborn screening (NBS) for mucopolysaccharidosis (MPS) II (Hunter syndrome; OMIM 309900). Electronic databases were searched in July 2023 for articles referencing NBS for lysosomal storage diseases: 53 featured MPS II. Until recently, only Taiwan and two US states (Illinois and Missouri) formally screened newborns for MPS II, although pilot programs have been conducted elsewhere (Japan, New York, and Washington).

Prevalence and characteristics of postoperative and nonoperative chronic hypoparathyroidism in Japan: a nationwide retrospective analysis.

Hypoparathyroidism is a rare endocrine disorder characterized by low serum calcium and elevated serum phosphorus levels. Patients who do not recover parathyroid function after surgeries or have nonsurgical causes involving congenital and metabolic diseases, require long-term use of active vitamin D and calcium supplementation as conventional therapy in Japan. This study aimed to estimate prevalence of chronic hypoparathyroidism and investigate its disease etiology, patient characteristics, and treatment in Japan, using a health insurance claim database.

Applying whole-genome and whole-exome sequencing in breast cancer: a review of the landscape.

Whole-genome sequencing (WGS) and whole-exome sequencing (WES) are crucial within the context of breast cancer (BC) research. They play a role in the detection of predisposed genes, risk stratification, and identification of rare single nucleotide polymorphisms (SNPs). These technologies aid in the discovery of associations between various syndromes and BC, understanding the tumour microenvironment (TME), and even identifying unknown mutations that could be useful in future for personalised treatments.