Transcranial Doppler sonography in headache-free migraineurs.

We used transcranial Doppler ultrasonography to determine whether intracranial blood velocities in 182 headache-free migraineurs (60 with aura, 122 without aura) differed from velocities in 38 nonheadache prone control subjects. During the headache-free period, migraineurs with and without aura had significantly elevated mean velocities in all intracranial arteries except the right internal carotid artery at the level of the siphon. Velocities in migraineurs with aura did not differ significantly from velocities in those without aura.

Community health nursing in the 1990s--risky business?

The atmosphere in which community health nurses (CHNs) work in city, suburban, and rural neighborhoods has become increasingly dangerous. Using Neuman's Systems Theory, four graduate students surveyed CHNs from three certified home health agencies to ascertain the real and perceived safety risks which these workers face daily. The response from all three agencies was similar as the nurses identified several situations in which they felt that their safety was compromised.

The application of 5-bromodeoxyuridine in the management of CNS tumors.

A variety of clinical reports have described the application of the bromodeoxyuridine labeling index as an adjunct to conventional pathological examination of CNS tumors. This index has proven useful in predicting the clinical outcome associated with many such tumors. Furthermore, because of its efficacy as a radiosensitizing agent, bromodeoxyuridine (and the closely related iododeoxyuridine) has been used in combination with radiation therapy for malignant glial neoplasms, with some encouraging results.

Mutually exclusive binding of two cellular factors within a critical promoter region of the gene for the IE110k protein of herpes simplex virus.

We have examined the cis- and trans-acting factors involved in constitutive transcription of the promoter for the IE110k protein of herpes simplex virus type 1. Our results indicate that while the IE110k gene is activated by Vmw65, it also exhibits very efficient constitutive expression approximating that from the simian virus 40 early enhancer-promoter region. We show that despite the presence of multiple copies of the octamer consensus site which mediate Oct-1 binding and subsequent Vmw65 activation, these upstream sequences have a minor effect on constitutive transcription.

Unilateral hemispheric memory and hippocampal neuronal density in temporal lobe epilepsy.

We examined the relationship of preoperative unilateral memory function and quantitative hippocampal histology in patients undergoing anterior temporal lobectomy for the treatment of complex partial seizures. Recognition memory (objects, words, figures) was assessed preoperatively for each hemisphere by the intracarotid amobarbital procedure in 23 patients (mean age at the time of operation, 30.2 yr; standard deviation, 9.

Patterns of genetic variation in Native America.

Allele frequencies from seven polymorphic red cell antigen loci (ABO, Rh, MN, S, P, Duffy, and Diego) were examined in 144 Native American populations. Mean genetic distances (Nei's D) and the fixation index FST are approximately equal for the North and South American samples but are reduced in the Central American geographic area. The relationship between genetic distance and geographic distance differs markedly across geographic areas.

The Galway Study of Panic Disorder. I: Clomipramine and lofepramine in DSM III-R panic disorder: a placebo controlled trial.

Among 79 volunteer, unpaid, family doctor-referred psychiatric out patients with DSM III-R panic disorder, with and without agoraphobia, 66 completed a six week placebo-controlled trial of lofepramine versus clomipramine and 57 survivors were followed up for 6 months. All subjects received one hour per week concurrent behavioural counselling in the acute phase. Of 13 dropouts in the first 3 weeks, 9 (of 27) were on clomipramine, 2 (of 26) were on lofepramine and 2 (of 26) were on placebo.

Psychological modulation of the delayed type hypersensitivity skin test.

Considerable data have demonstrated that psychological states can influence the immune system in animals. Whether human immune function can be intentionally modulated by the central nervous system is unknown. This article presents data from two studies that sought to demonstrate intentional modulation of the immune system by psychological interventions.

Treatment of seasonal depression with d-fenfluramine.

Eighteen patients with seasonal affective disorder (SAD) participated in a double-blind, placebo-controlled crossover study in 1986-1987. Each received, in random order, d-fenfluramine (15 mg p.o.

Nutrient imbalances in depressive disorders. Possible brain mechanisms.

We examined the utility of d-fenfluramine, a serotonin-releasing drug previously shown to diminish carbohydrate craving and weight gain in obese people, in treating patients with seasonal affective disorder (SAD), a variant of depression that occurs each fall and winter and is usually associated with hyperphagia and carbohydrate craving. Eighteen patients participated in a double-blind, placebo-controlled study in 1986-1987, each receiving, in random order, d-fenfluramine (15 mg p.o.

Return to work after a first myocardial infarction. A test of multiple hypotheses.

The relationship between return to work within one year after a first myocardial infarction and selected sociodemographic, health, psychosocial, and vocational characteristics was assessed in 151 patients aged 24 to 70 years. Seventy-two percent of the sample returned to work. Education, physical activity associated with employment, severity of myocardial infarction, perception of health status, financial incentives, socioeconomic status, treatment hospital, rated social health status, locus of control, satisfaction with work, and early entry into the job force each proved to be significantly associated with return to work in independent univariate analyses.

Genetics of primate lymphomas in a baboon (Papio hamadryas) colony of Sukhumi, USSR.

A lymphoma outbreak occurred at the Sukhumi Center in the Late 1960's, when 12 baboons were inoculated with blood from human leukemia patients. Out of a total of 3219 animals, 218 contracted lymphoma and died. This outbreak appears to be primarily horizontal in transmission.

Control of masseter muscle tension during sleep.

This study evaluated whether muscle tension could be controlled during sleep. Twelve volunteers were assigned to an experimental condition or to a no treatment control group. Experimental subjects were instructed to reduce the tension in their masseter (jaw) muscle when signalled with an auditory tone.

Influence of personal and universal failure on the subsequent performance of persons with type A and type B behavior patterns.

We conducted this experiment to compare the task performance of Type A and Type B persons following failure on a task in which no one succeeded (universal failure) versus failure on a task in which others had succeeded (personal failure). Postfailure performance was measured in terms of speed of completion of anagrams. Initial analyses indicated that the failure manipulation was effective in influencing the subjects' perceived cause of their failures, and that subjects were more anxious and depressed following personal failure than universal failure.

Geographic distribution of consanguinity in Europe.

Average consanguinity (alpha) of 20 large regional or national samples derived from Roman Catholic Dispensations or state archives shows a strong negative relationship with latitude (r = -0.738; P less than 0.001) which seems best explained by cultural-historical factors.

Patterns and correlates of genetic variation in South Amerindians.

Gene frequency data from six polymorphic blood group systems in 70 South American Indian populations are used to derive synthetic gene frequency maps that document the geographical pattern of genetic variation. Additional analyses are directed toward the elucidation of mechanisms that give rise to or maintain the observed distributions. Variables of local ecology do not appear to explain gene frequency distributions in South America.