Prediction of steady-state trough serum procainamide concentrations after administration of a sustained-release procainamide preparation.

Four methods of predicting steady-state trough serum procainamide concentrations (SPC) were compared in 15 patients receiving sustained-release procainamide (Procan-SR) therapy. All methods were based on a one-compartment pharmacokinetic model. Method 1 utilized nine initial measured SPC and individualized pharmacokinetic parameters for prediction of the steady-state SPC.

p53 and transformation by SV40.

The large T antigen of SV40 is able to immortalize and transform primary and established cells in culture, and can, at least in certain cases, confer a tumorigenic phenotype on the infected cell. T antigen has been shown to induce cellular DNA synthesis in the infected cell and this activity is likely to be instrumental in T antigen mediated oncogenesis. A property of T antigen which may be of paramount importance to its oncogenic and mitogenic activities is its ability to specifically bind and stabilize the cellular protein p53.

A protein of squamous keratinising epithelium from odontogenic keratocyst fluid.

Fluid from odontogenic keratocysts was analysed. The major protein fraction with a mobility anodal to albumin on electrophoresis was shown not to be albumin or pre-albumin but a non-serum protein. Using an antiserum to keratocyst fluid absorbed with human serum, non-serum components of the odontogenic keratocyst fluid were localised in squamous keratinising epithelia, principally in the upper layers.

Increased ammoniagenesis and the renal tubular effects of potassium depletion.

The cause of the morphological changes and functional defects in the renal tubule seen in patients with severe potassium depletion is unknown. In man and animals potassium status is a major factor regulating ammonia synthesis in the kidney and urinary ammonium excretion. A primary effect of potassium depletion is to cause an increase in ammoniagenesis by the renal tubular cells.

Pathology of the heart and the cardiac conduction system in Wegener's granulomatosis.

Two cases of Wegener's granulomatosis occurred in two women aged 53 and 67 years. The clinical course in both was of rapid deterioration resulting from renal failure and leading to death. At necropsy both cases showed severe and disseminated necrotising granulomatosis in the lungs, kidneys, and spleen but with variable degrees of cardiac and systemic vasculitis.

Distribution of portal blood flow in the liver of the rat: a microsphere study.

We sought to determine whether streamlining of portal venous blood occurs in normal anaesthetized rats under basal conditions and with variations in hepatic blood flow. We catheterized the ileocolic vein and injected 15 micron microspheres labeled with 85Sr and 141Ce into this vein and into the spleen, respectively. The hepatic lobar distribution of microspheres was studied in a group under basal conditions and after hepatic blood flow was increased (infusions of nitroglycerin or glucagon) or decreased (infusion of vasopressin or ligation of the superior mesenteric artery); this blood flow was measured with a constant infusion of indocyanine green.

Portal-systemic shunting and the hemodynamic effects of nitroglycerin in the rat.

A hemodynamic response to oral nitroglycerin has been used recently to estimate the extent of portal systemic shunts in humans. We studied the hemodynamic effects of this drug in the rat with partial portal vein ligation, a model in which portal hypertension develops and the extent of portal-systemic collaterals can be measured. Two to ten days after the initial procedure, shunted and sham-operated controls received a continuous infusion of nitroglycerin into a jugular vein, the ileocolic vein, or intrajejunally.

Heterotopic pancreas mimicking carcinoma of the head of the pancreas: a rare cause of obstructive jaundice.

A 61-year-old man developed obstructive jaundice and had ultrasonographic and cholangiopancreatographic findings consistent with carcinoma of the pancreas. However, pathologically the obstruction proved to be from heterotopic pancreatic tissue compressing the common bile duct. This patient and eight previously reported patients with a similar problem are the subjects of this report.

Etiological factors in cerebral palsy: an historical review.

The etiological factors in 1503 patients with cerebral palsy seen since 1947 are listed. Prematurity was the most prominent factor, being present in 27.8 per cent of cases.

Biochemical findings in a case of mu-chain disease.

We report the 16th case of mu-chain disease. Unlike most previously reported cases, free mu-chains, but not Bence Jones protein, were present in the urine. The usefulness of immunofixation as a means of detecting free heavy chains in the serum is demonstrated.

Experience with a sliding screw in intertrochanteric fractures.

A retrospective study of our first year's experience with a sliding screw in intertrochanteric fractures was conducted. Forty-five patients with intertrochanteric fractures were admitted to St. Louis City Hospital in the year considered.

Fibular strut grafting for giant cell tumors of the proximal tibia.

Fibular strut grafting in association with curettage and iliac bone grafting is presented as a method of initial treatment of juxta-articular giant cell tumor of tibia. Using the fibula strut to support the articular surface, the reported cases demonstrate rapid return of knee motion and early functional weight bearing.