Publications by authors named "Nyung Kim"
Article Synopsis
- The study compared the pharmacokinetic (PK) and safety profiles of two fenofibric acid formulations, a 135 mg capsule and a 110 mg enteric-coated tablet, under fasting and fed conditions.
- Conducted as a crossover phase 1 clinical trial with 120 healthy Korean men, blood samples were analyzed to assess how each formulation performed over 72 hours.
- Results showed that the enteric-coated tablet had better bioavailability and was easier to swallow, taking longer to reach peak concentration than the capsule in both fasting and fed states.
An highly quaternary and unprecedented dispiro compound, verrulactone C, with the known compound, altenuisol, were isolated from a culture broth of the fungal strain Penicillium verruculosum F375 and their structures were established by various spectral analysis. Verrulactone C and altenuisol showed FabI-selective inhibition. Especially altenuisol had the high correlation between FabI-inhibition and whole cell antibacterial activity against Staphylococcus aureus and MRSA with MICs of 8-32μg/mL.
View Article and Find Full Text PDFNew dimeric compounds of alternariol class, verrulactones A and B, were isolated from a culture broth of the fungal strain Penicillium verruculosum F375 and their structure were established by various spectral analysis. Verrulactones A and B strongly inhibited Staphylococcus aureus enoyl-ACP reductase with IC(50) of 0.92 and 1.
View Article and Find Full Text PDF