Publications by authors named "Nyer M"

Article Synopsis
  • A study was conducted on 80 participants with moderate-to-severe depression, who participated in an 8-week trial of heated Bikram yoga to evaluate its effects on their mental health.
  • Participants reported immediate improvements in their depressive symptoms after yoga sessions, with most noting overall positive effects throughout the intervention, such as better sleep, mood, and energy levels.
  • However, some participants also expressed negative experiences with the classes, including dissatisfaction with instruction, difficulty, and boredom, though the majority reported mixed feelings with both positive and negative effects.
View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to explore the effects of whole-body hyperthermia on major depressive disorder by examining the role of interleukin-6 signaling as a potential therapeutic target.
  • The randomized, double-blind trial involved 30 participants, who either underwent hyperthermia treatment or a sham condition, with evaluations of depression symptoms and blood markers before and after the intervention.
  • Results indicated that only the hyperthermia group showed a significant increase in the IL-6:soluble IL-6 receptor ratio post-treatment, which correlated with reduced depressive symptoms over the following weeks.*
View Article and Find Full Text PDF

The popularity of yoga has surged in recent years; however, yoga practitioners have remained a largely homogenous population. Research reflects that most practitioners are of a higher socioeconomic status. There are access barriers to yoga for lower income individuals, likely due to factors such as financial constraints and logistical challenges.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the relationship between body temperature and depression, hypothesizing that more severe depressive symptoms correlate with higher body temperature, smaller temperature differences between awake and asleep states, and lower temperature amplitude throughout the day.* -
  • Using data from over 20,000 participants, the research found that both self-reported and wearable sensor data indicated higher body temperatures were linked to greater depression severity.* -
  • While lower diurnal temperature amplitude also showed a trend towards being associated with higher depression severity, this result wasn’t statistically significant, suggesting that body temperature changes could be important in understanding and treating major depressive disorder.*
View Article and Find Full Text PDF

To evaluate feasibility, acceptability, and preliminary efficacy of heated yoga to treat moderate-to-severe depression. An 8-week randomized controlled trial (RCT) of heated yoga versus waitlist control was conducted from March 2017 to August 2019. Participants in the yoga condition were asked to attend heated yoga classes at 2 community heated yoga studios at least twice weekly.

View Article and Find Full Text PDF

Background: Sexual minorities are at a higher risk of suffering from depressive symptoms compared with heterosexual individuals. Only a few studies have examined the conditions of having depressive symptoms within different sexual minority groups, especially people with sexual orientation uncertainty in a nationally representative sample. Furthermore, few studies have explored whether the mean white blood count (WBC) is different between people with and without depressive symptoms among different sexual minority groups in a nationally representative sample.

View Article and Find Full Text PDF

Background: Herpes Simplex Virus Type 2 (HSV-2) has been associated with depression, but the relationship has yet to be explored with respect to gender and sexual orientation in a nationally representative sample to help identify individuals at higher risk for depression.

Methods: A dataset from National Health and Nutrition Examination Survey 2009-2014 was used in this study. Multivariable logistic regression models were constructed to test effect modification on both the multiplicative and additive scale using a sample of 57,684 subjects.

View Article and Find Full Text PDF

Background: Family caregivers of dementia patients experience high levels of interpersonal stress that often results in elevated anxiety, and depression, and negative impacts on interpersonal relationships. Changes in behaviors and the structure of relationships with the care recipient (CR) and others in the social milieu challenge the caregivers' ability to mentalize, or understand the links between mental states and behaviors. This study investigates the experiences and perceived benefits of family dementia caregivers who underwent Mentalizing Imagery Therapy (MIT), a treatment aiming to improve balanced self-other mentalizing and reduce psychological symptoms.

View Article and Find Full Text PDF
Article Synopsis
  • Over 50 million people globally have dementia, with most being cared for by family members who often face chronic stress and insomnia, negatively impacting their health.
  • Mentalizing imagery therapy (MIT) offers mindfulness techniques to help caregivers manage stress, but integrating it with caregiver skills training has not been previously explored.
  • A study will investigate the effectiveness of a smartphone app delivering MIT alongside caregiver training, aiming to reduce stress and insomnia in 120 caregivers while also collecting data to identify health-related behavioral patterns.
View Article and Find Full Text PDF

Introduction: Family caregivers of patients with dementia suffer a high burden of depression and reduced positive emotions. Mentalizing imagery therapy (MIT) provides mindfulness and guided imagery skills training to improve balanced mentalizing and emotion regulation.

Objective: Our aims were to test the hypotheses that MIT for family caregivers would reduce depression symptoms and improve positive psychological traits more than a support group (SG), and would increase dorsolateral prefrontal cortex (DLPFC) connectivity and reduce subgenual anterior cingulate cortex (sgACC) connectivity.

View Article and Find Full Text PDF

Background: Prevention programs that are 'transdiagnostic' may be more cost-effective and beneficial, in terms of reducing levels of psychopathology in the general population, than those focused on a specific disorder. This randomized controlled study evaluated the efficacy of one such intervention program called Resilience Training (RT).

Methods: College students who reported mildly elevated depressive or subclinical psychotic symptoms ('psychotic experiences' (PEs)) ( = 107) were randomized to receiving RT ( = 54) or to a waitlist control condition ( = 53).

View Article and Find Full Text PDF

Depression remains difficult to treat as a result of less than optimal efficacy and troublesome side effects of antidepressants. The authors present the case of a patient with treatment-resistant depression with melancholic features who had previously been unresponsive to electroconvulsive therapy (ECT) plus an antidepressant regimen but whose condition fully remitted with the addition of a standardized form of heated hatha yoga (HY; Bikram yoga) practiced in a room heated to 105°F. The patient was a 28-year-old woman who underwent 8 weeks of HY as part of a randomized controlled trial of HY for depression while continuing her antidepressant treatment.

View Article and Find Full Text PDF

Background: Telehealth has provided many researchers, especially those conducting psychosocial research, with the tools necessary to transition from in-person to remote clinical trials during the COVID-19 pandemic. A growing body of research supports the effectiveness of telemental health for a variety of psychiatric conditions, but few studies have examined telemental health for individuals with comorbid medical diagnoses. Furthermore, little is known about the remote implementation of clinical trials examining telemental health interventions.

View Article and Find Full Text PDF

Background: Emerging data suggest cannabis use is a component cause of psychotic disorders; however, the sequence of processes accounting for this association is poorly understood. Some clues have come from studies in laboratory settings showing that acute cannabis intoxication is associated with subclinical hallucinations and delusional thinking, i.e.

View Article and Find Full Text PDF

While preliminary evidence suggests that sensors may be employed to detect presence of low mood it is still unclear whether they can be leveraged for measuring depression symptom severity. This study evaluates the feasibility and performance of assessing depressive symptom severity by using behavioral and physiological features obtained from wristband and smartphone sensors. Participants were thirty-one individuals with Major Depressive Disorder (MDD).

View Article and Find Full Text PDF

Objective: Both cognitive behavioral therapy for depression (CBT-D) combined with brief motivational interviewing (CBT-D + BMI) and alone are associated with symptom improvement among college students with co-occurring depression and heavy episodic drinking (HED). However, little is known about change processes underlying these different treatments.The current study uses a network approach to examine change process that may differentially underlie CBT-D + BMI relative to CBT alone.

View Article and Find Full Text PDF

Objective: Low-dose testosterone has been shown to improve depression symptom severity, fatigue, and sexual function in small studies in women not formally diagnosed with major depressive disorder. The authors sought to determine whether adjunctive low-dose transdermal testosterone improves depression symptom severity, fatigue, and sexual function in women with antidepressant-resistant major depression. A functional MRI (fMRI) substudy examined effects on activity in the anterior cingulate cortex (ACC), a brain region important in mood regulation.

View Article and Find Full Text PDF

Objective: The neuroactive steroid metabolite of progesterone, allopregnanolone, is a positive allosteric modulator of γ-aminobutyric acid-A (GABAA) receptors and a putative treatment for mood disorders. This pilot study was performed to determine whether an oral allopregnanolone analog (ganaxolone) may be effective adjunctive therapy for persistent depression despite adequate antidepressant treatment in postmenopausal women.

Method: Ten postmenopausal women (mean ± SD age: 62.

View Article and Find Full Text PDF