Non-invasive brain stimulation enhances motor and cognitive performances during dual tasks in patients with Parkinson's disease: a systematic review and meta-analysis.

Background: Parkinson's disease (PD) induces progressive deficits in motor and cognitive functions as well as impaired dual-task performance requiring both motor and cognitive functions. This systematic review and meta-analysis evaluated the effects of non-invasive brain stimulation (NIBS) on dual-task performance in patients with PD.

Methods: 11 studies met the following inclusion criteria: (a) patients with PD, (b) NIBS intervention, (c) comparison with the sham stimulation group, (d) motor and cognitive performance outcomes during dual tasks, and (e) randomized controlled trials with parallel or crossover designs.

Transcranial direct current stimulation improves heart rate variability: A systematic review and meta-analysis.

Background: Heart rate variability (HRV) is a useful tool for evaluating cardiovascular autonomic nervous system (ANS) functions. This systematic review and meta-analysis examined the potential effects of transcranial direct current stimulation (tDCS) protocols on HRV parameters.

Methods: This study acquired 97 comparisons from 24 qualified studies for data synthesis.

Resistance band training with functional electrical stimulation improves force control capabilities in older adults: a preliminary study.

Resistance band training (RBT) with functional electrical stimulation (FES) may be an effective exercise regimen for improving age-related motor impairments. This preliminary study investigated the potential effects of bimanual RBT with FES on upper limb motor functions in older adults. This study randomly assigned 22 elderly people to the bimanual RBT with FES (Bi-RBT+FES) group and the RBT without FES (Bi-RBT) group.

Effects of visual feedback and force level on bilateral ankle-dorsiflexion force control.

This study investigated the potential effects of visual feedback and force level on bilateral force control capabilities in the lower limbs. Thirty-nine healthy young adults performed bilateral ankle-dorsiflexion isometric force control tasks for different visual feedback conditions, including continuous visual feedback (CVF) and withdrawal of visual feedback (WVF), indicating the removal of visual feedback on force outputs during the task and force level conditions (i.e.

Advanced Force Coordination of Lower Extremities During Visuomotor Control Task in Soccer Players.

: This study is aimed to determine specific bilateral lower extremity motor performances and coordination patterns in soccer players with healthy controls using the bilateral force control paradigm. We hypothesized that soccer players would show more advanced bilateral force control performances than untrained controls. : Participants were 13 university soccer players and 13 healthy controls.

Associations of Orthostatic Hypotension and Orthostatic Intolerance with Domain-Specific Cognitive Decline in Patients with Early Parkinson Disease: An 8-Year Follow-up.

Objective: Although orthostatic hypotension (OH) and orthostatic intolerance (OI) are prevalent in patients with Parkinson disease (PD), it remains unclear how these conditions primarily affect the trajectory of decline in specific cognitive domains. This study aimed to explore the effects of OH and OI on longitudinal domain-specific cognitive changes in patients with PD.

Design: An 8-year follow-up of the Parkinson Progression Markers Initiative cohort study.

Effects of physical exercise interventions on cognitive function in Parkinson's disease: An updated systematic review and meta-analysis of randomized controlled trials.

Objective: To determine whether physical exercise interventions can improve cognitive function, including overall performance and specific domains, in patients with Parkinson's disease (PD) and to provide potential evidence on how cognitive benefits can be optimized by exercise prescriptions.

Methods: Using PubMed, Web of Science, and Cochrane Library (from inception to August 2022), four independent reviewers screened the search results and extracted data from randomized controlled trials of physical exercise interventions in patients with PD with an outcome measure of cognitive function. Random-effects meta-analysis models were used to report standardized mean differences (SMDs) with 95 % confidence intervals (CIs).

Effects of high-intensity interval training and moderate-intensity continuous training on sarcopenia-related parameters in participants with Parkinson's disease: A 24-week randomized pilot trial substudy.

Objective: To evaluate the potential efficacy of two different supervised exercise regimens, namely high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT), on sarcopenia-related parameters in participants with Parkinson's disease (PD).

Methods: We analyzed data from a randomized controlled pilot trial (CRIS identifier: KCT0007130). An aerobic exercise intervention using a cycle ergometer (40-60 min) in combination with calisthenics (5 min) was performed in three sessions/week for 24 weeks for HIIT (60% maximum aerobic power for 30-50 s with 1-min rest intervals) and MICT (50% peak oxygen consumption) groups.

Dual-hemisphere anodal transcranial direct current stimulation improves bilateral motor synergies.

Transcranial direct current stimulation (tDCS) is one of the non-invasive brain stimulation techniques that can improve motor functions. As bimanual motor actions require high motor cortical activations between hemispheres, applying bilateral anodal stimulation on left and right sides of primary motor cortex (M1) can improve for improvements in bimanual motor tasks. This study investigated which bilateral tDCS protocol effectively improves bimanual hand-grip force control capabilities in healthy young adults.

Repetitive transcranial magnetic stimulation improves cardiovascular autonomic nervous system control: A meta-analysis.

Background: Cardiovascular autonomic system (ANS) may be affected by altered neural activations in the brain. This systematic review and meta-analysis investigated potential effects of repetitive transcranial magnetic stimulation (rTMS) protocols on cardiovascular ANS control.

Methods: Through 19 qualified studies, we acquired 70 comparisons for data synthesis.

Prognostic significance of peripheral neutrophils and lymphocytes in early untreated Parkinson's disease: an 8-year follow-up study.

Background: To explore whether peripheral blood neutrophils and lymphocytes are associated with longitudinal motor and cognitive decline in patients with early Parkinson's disease (PD) and, to uncover the disease-specific mechanisms underlying these associations.

Methods: Data were obtained from the Parkinson's Progression Markers Initiative cohort. We included 376 patients with recently diagnosed, drug-naïve PD and 178 matched healthy controls.

Altered Bimanual Kinetic and Kinematic Motor Control Capabilities in Older Women.

Older women may experience critical neuromuscular impairments interfering with controlling successful bimanual motor actions. Our study aimed to investigate altered bimanual motor performances in older women compared with younger women by focusing on kinetic and kinematic motor properties. Twenty-two older women and 22 younger women performed bimanual kinetic and kinematic motor tasks.

A meta-analysis showing improved cognitive performance in healthy young adults with transcranial alternating current stimulation.

Transcranial alternating current stimulation (tACS) is a non-invasive brain stimulation used for improving cognitive functions via delivering weak electrical stimulation with a certain frequency. This systematic review and meta-analysis investigated the effects of tACS protocols on cognitive functions in healthy young adults. We identified 56 qualified studies that compared cognitive functions between tACS and sham control groups, as indicated by cognitive performances and cognition-related reaction time.

Transcranial direct current stimulation influences repetitive bimanual force control and interlimb force coordination.

This study aimed to investigate the potential effect of bilateral transcranial direct current stimulation (tDCS) on repetitive bimanual force control and force coordination in healthy young adults. In this sham-controlled crossover study, 18 right-handed young adults were enrolled. Repetitive bimanual handgrip force control trials were performed by the participants at 40% of maximum voluntary contraction until task failure.

Bimanual motor impairments in older adults: an updated systematic review and meta-analysis.

This updated systematic review and meta-analysis further examined potential effects of aging on bimanual movements. Forty-seven qualified studies that compared bimanual motor performances between elderly and younger adults were included in this meta-analysis. Moderator variable analyses additionally determined whether altered bimanual motor performances in older adults were different based on the task types (i.

Unilateral hand force control impairments in older women.

Older women may experience deficits in sensorimotor control at their upper limb because of aging progress compromising the motor system. This study aimed to investigate whether younger and older women differ in sensorimotor capabilities assessed by unilateral force control performances at a lower targeted force level. Twenty-one older and 21 younger women performed isometric unilateral force control tasks at 10 % of maximum voluntary contraction for each hand, respectively.

Higher visual gain contributions to bilateral motor synergies and force control.

This study investigated the effects of altered visual gain levels on bilateral motor synergies determined by the uncontrolled manifold (UCM) hypothesis and force control. Twelve healthy participants performed bimanual index finger abduction force control tasks at 20% of their maximal voluntary contraction across four different visual gain conditions: 8, 80, 256, and 512 pixels/N. Quantifying force accuracy and variability within a trial provided a bimanual force control outcome.

Association of Early Weight Change With Cognitive Decline in Patients With Parkinson Disease.

Background And Objective: To examine whether early weight change is associated with subsequent deterioration in cognitive function, including overall performance and specific domains, in Parkinson disease (PD).

Methods: This observational study used data from the Parkinson Progression Markers Initiative cohort. The patients underwent annual nonmotor assessments covering neuropsychiatric, sleep-related, and autonomic symptoms for up to 8 years of follow-up.

Effects of Exercise on Depressive Symptoms in Patients With Parkinson Disease: A Meta-analysis.

Background And Objective: The purpose of this study was to provide clear evidence in support of the use of exercise to improve depressive symptoms in patients with Parkinson disease (PD) and to investigate whether this effect differs by exercise type and intensity.

Methods: Three independent reviewers searched for randomized controlled trials (RCTs) that applied exercise interventions with depressive symptoms as an outcome measure for patients with PD on PubMed and Web of Science up to February 28, 2022. Random-effects meta-analyses were performed, in which standardized mean differences (SMDs) between the effects of exercise and control interventions on depressive symptoms with 95% CIs were calculated.

A Review and Meta-Analysis of Interactive Metronome Training: Positive Effects for Motor Functioning.

Interactive metronome training may be effective for improving motor performances through timing. In this systematic review and meta-analysis, 18 prospective studies met our eligibility criteria, and we summarized the effects of interactive metronome training protocols on motor functioning. We estimated effect sizes by quantifying differences in altered motor functions between participants in interactive metronome training and control groups.

Effects of Patellofemoral Pain Syndrome on Changes in Dynamic Postural Stability during Landing in Adult Women.

Background: This study investigated the effects of lower limb movements on dynamic postural stability (DPS) during drop landing in adult women with patellofemoral pain syndrome (PFPS).

Methods: Thirty-eight adult women were recruited and divided into two groups, the PFPS group and the control group. The study participants performed a single-leg drop landing from a 30 cm box, and their lower limb movements and DPS were measured.

Increased Cerebellar Gray Matter Volume in Athletes: A Voxel-Wise Coordinate-Based Meta-Analysis.

: The purpose of this systematic review and meta-analysis study was to investigate distinct brain structural characteristics in athletes as compared with those in non-athletes by quantifying regional gray matter (GM) volume changes using voxel-based morphometry analysis based on a whole-brain approach. : The systematic literature search was conducted from November 1, 2020 to October 18, 2021 via the two search engines including the PubMed and Web of Science. We included 13 studies that reported GM volume data in 229 athletes as compared 219 non-athletes based on the whole-brain analysis with specific three-dimensional coordinates in a standard stereotactic space.

Different unilateral force control strategies between athletes and non-athletes.

This study investigated continuous visuomotor tracking capabilities between athletes and non-athlete controls using isometric force control paradigm. Nine female athletes and nine female age-matched controls performed unilateral hand-grip force control tasks with their dominant and non-dominant hands at 10% and 40% of maximal voluntary contraction (MVC), respectively. Three conventional outcome measures on force control capabilities included mean force, force accuracy, and force variability, and we additionally calculated two nonlinear dynamics variables including force regularity using sample entropy and force stability using maximal Lyapunov exponent.

Visual feedback improves bimanual force control performances at planning and execution levels.

The purpose of this study was to determine the effect of different visual conditions and targeted force levels on bilateral motor synergies and bimanual force control performances. Fourteen healthy young participants performed bimanual isometric force control tasks by extending their wrists and fingers under two visual feedback conditions (i.e.