Publications by authors named "Nydia Jaimes-Delgadillo"
Unconjugated monoclonal antibodies (mAb) have revolutionized the treatment of many types of cancer. Some of these mAbs promote the clearance of malignant cells via direct cytotoxic effects. More recently, antibody-dependent cellular phagocytosis (ADCP) has been appreciated as a major mechanism of action for a number of widely-used mAbs, including anti-CD20 (rituximab, obinutuzumab), anti-HER2 (trazituzumab), and anti-CD38 (daratumumab).
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- Breast cancer is a major health issue, and the study focuses on Prolactin Induced Protein (PIP), which was found to be expressed differently in breast cancer (BC) tissues compared to normal tissues.
- Researchers used real-time quantitative PCR and immunohistochemistry on various samples to analyze PIP expression, categorizing tumor specimens based on classification and subtype.
- Findings showed that PIP mRNA is significantly downregulated in early-stage BC, indicating its potential as a biomarker that could help pathologists in diagnosing early-stage breast cancer.