Menopausal women have hypofibrinolysis even in subclinical stage of atherosclerosis.

Background: PAI-1 is the main inhibitor of fibrinolysis. Increase in PAI-1 levels has been associated with the risk of coronary disease; however, there are few studies on the relationship between subclinical atherosclerosis and PAI-1 levels.

Objective: The aim of this study was to analyze the relationship between PAI-1 level and carotid intima-media thickness in premenopausal and postmenopausal women without apparent cardiovascular disease.

Epicardial adipose tissue is associated with visceral fat, metabolic syndrome, and insulin resistance in menopausal women.

Introduction And Objectives: Epicardial adipose tissue has been associated with several obesity-related parameters and with insulin resistance. Echocardiographic assessment of this tissue is an easy and reliable marker of cardiometabolic risk. However, there are insufficient studies on the relationship between epicardial fat and insulin resistance during the postmenopausal period, when cardiovascular risk increases in women.

[Clinical improvement of diabetic neuropathy with carbamazepine or diclofenac treatment].

Background: diabetic neuropathy (DN) affects diverse aspects of a patient's life and there is not an optimal treatment. We did a comparative study of clinical improvement of DN with carbamazepine versus diclofenac.

Methods: a prospective and longitudinal study of two groups with signs and symptoms of DN was done.

[Frequency of symptoms of the climacteric syndrome].

Background: Menopause is the descent in circulating estrogens that manifests clinically for the climacteric symptoms. These symptoms motivate the patient to consult to the physician.

Objective: To know which are the symptoms that motivate women in the climacteric to begin hormonal therapy.

[Hypothyroidism associated to menopause symptoms worsening change with thyroid substitution therapy].

Background: Hypothyroidism is more frequent in woman and raises with age. It is not clear why do they have greater susceptibility, but it seems to be related with levels of estrogens and hormonal changes.

Objective: To evaluate changes in symptoms of women with menopause and hypothyroidism after receiving hypothyroidism therapy and later hormonal therapy.