Sea level rise and coastal flooding risks in the Gulf of Guinea.

The Gulf of Guinea (GoG) is highly vulnerable to sea level rise, with projections indicating a significant increase in permanently inundated land by 2100, ranging from 1,458.1 to 4,331.7 km.

 (Caryophyllaceae), an enigmatic new species from Kaua'i, Hawaiian Islands and the first species discovered by a drone collection system.

During a survey by the National Tropical Botanical Garden drone team, an enigmatic was observed in December 2021on steep, rocky cliff faces of the Waiahulu Valley in the Waimea Canyon of Kaua'i. Subsequently, another survey was conducted in March 2022 and, by use of a remotely controlled cutting device suspended below the drone, the first herbarium specimen was collected, as well as a seed collection of an undescribed cliff-dwelling species of . Detailed study of the collections and plants grown at the University of California, Irvine greenhouse showed that it had enlarged, somewhat whitish sepals similar to those of cliff-dwelling (the sole species in sect.

Sea level variability in Gulf of Guinea from satellite altimetry.

Coastal zones with dense populations, low elevations and/or inadequate adaptive capacity are on the frontline of unprecedented impacts from climate change. The Gulf of Guinea (GoG), stretching from Liberia to Gabon, is in particular vulnerable to coastal flooding caused by local and/or climate-induced sea level rise. In this region, interannual to decadal coastal sea level changes remain poorly understood, mainly due to a lack of tide gauge stations.

Global scale analysis on the extent of river channel belts.

Rivers form channel belts that encompass the area of the river channel and its associated levees, bars, splays and overbank landforms. The channel belt is critical for understanding the physical river evolution through time, predicting river behavior and management of freshwater resources. To date, there is no global-scale, quantitative study of the extent of river channel belts.

Leaving a plastic legacy: Current and future scenarios for mismanaged plastic waste in rivers.

Mismanaged plastic waste (MPW) entering the riverine environment is concerning, given that most plastic pollution never reaches the oceans, and it has a severe negative impact on terrestrial ecosystems. However, significant knowledge gaps on the storage and remobilization of MPW within different rivers over varying timescales remain. Here we analyze the exposure of river systems to MPW to better understand the sedimentary processes that control the legacy of plastic waste.

Collecting critically endangered cliff plants using a drone-based sampling manipulator.

Kaua'i, an island within the Hawai'i archipelago, is home of a unique flora that contains 250 single-island endemic plant species. Threats have led to a significant population decrease where 97% of these plant species are now listed as endangered, critically endangered, or extinct. Vertical cliff habitats on Kaua'i work as refugia to protect plants from their stressors.

Extinction risk of the endemic vascular flora of Kauai, Hawaii, based on IUCN assessments.

The International Union for Conservation of Nature's Red List of Threatened Species (IUCN Red List) is the world's most comprehensive information source on the global conservation status of species. Governmental agencies and conservation organizations increasingly rely on IUCN Red List assessments to develop conservation policies and priorities. Funding agencies use the assessments as evaluation criteria, and researchers use meta-analysis of red-list data to address fundamental and applied conservation science questions.

Exposure of coastal environments to river-sourced plastic pollution.

Marine litter is a global problem which poses an increasing threat to ecosystem services, human health, safety and sustainable livelihoods. In order to better plan plastic pollution monitoring and clean-up activities, and to develop policies and programmes to deter and mitigate plastic pollution, information is urgently needed on the different types of coastal ecosystem that are impacted by land-sourced plastic inputs, especially those located in proximity to river mouths where plastic waste is discharged into the ocean. We overlayed the most current existing information on the input of plastic to the sea from land-based sources with maps of coastal environments and ecosystems.

Factors That Protect Children From Community Violence: Applying the INSPIRE Model to a Sample of South African Children.

Community violence is a prevalent form of interpersonal violence in South Africa for children living in low-income areas. Trauma arising from violence exposure is of concern in contexts where access to treatment is often unattainable. As simultaneous multisectoral strategies show higher potential to counter interpersonal violence than single interventions, the World Health Organization with partners created INSPIRE.

'It's a matter of patient safety': understanding challenges in everyday clinical practice for achieving good care on the surgical ward - a qualitative study.

Background: Surgical care plays an important role in the acute hospital's delivery of safe, high-quality patient care. Although demands for effectiveness are high in surgical wards quality of care and patient safety must also be secured. It is therefore necessary to identify the challenges and barriers linked to quality of care and patient safety with a focus on this specific setting.

Simultaneous detection of IgA and IgG antibodies against tissue transglutaminase: The preferred pre-biopsy test in childhood celiac disease.

Objectives: IgA antibodies against tissue transglutaminase (anti-TG2) is a reliable marker of celiac disease (CD). However, IgA-deficient patients are not identified and young children may lack IgA anti-TG2. Combined detection of IgA and IgG (IgA/IgG) against deamidated gliadin peptides (DGP) has shown a high diagnostic performance for untreated CD.

What strategies are appropriate for monitoring children outside of family care and evaluating the impact of the programs intended to serve them?

Objectives: To strengthen the evidence-base for policy and practice for support of children outside of family care requires effective, efficient and sustainable mechanisms for monitoring and evaluation. Toward that end, two core questions guided a systematic review of evidence: What strategies are appropriate for monitoring the needs and circumstances of children outside of family care? What strategies are suitable for evaluating the impact of the programs intended to serve such children?

Methods: A structured document search and review process was implemented within the context of the U.S.

Saving lives for a lifetime: supporting orphans and vulnerable children impacted by HIV/AIDS.

President's Emergency Plan for AIDS Relief (PEPFAR's) response to the millions of children impacted by HIV/AIDS was to designate 10% of its budget to securing their futures, making it the leading supporter of programs reaching orphan and vulnerable children (OVC) programs globally. This article describes the evolution of PEPFAR's OVC response based on programmatic lessons learned and an evergrowing understanding of the impacts of HIV/AIDS. In launching this international emergency effort and transitioning it toward sustainable local systems, PEPFAR helped establish both the technical content and the central importance of care and support for OVC as a necessary complement to biomedical efforts to end the HIV/AIDS epidemic.

Intestinal lymphocytic epithelioganglionitis: a unique combination of inflammation in bowel dysmotility: a histopathological and immunohistochemical analysis of 28 cases.

Aims: Visceral inflammatory neuropathies are enteric disorders underlying various forms of bowel dysmotility. The aim was to analyse the microscopic characteristics of a unique combination of intraepithelial lymphocytosis and myenteric ganglioneuritis.

Methods And Results: Paraffin sections of full-thickness proximal jejunal biopsy specimens from 28 patients, with proven disorders of gastrointestinal motility, were analysed following conventional and immunohistochemical staining.

Full-thickness biopsy findings in chronic intestinal pseudo-obstruction and enteric dysmotility.

Background And Aims: Small bowel manometry is increasingly used in the clinical investigation of patients with symptoms of intestinal motor dysfunction. Enteric dysmotility (ED) has been suggested as a new diagnostic term for patients with abnormal intestinal motor activity but no radiological signs of chronic intestinal pseudo-obstruction (CIP). Histopathological features of adult patients with ED and CIP have been compared in a large case series to study differences and similarities between the two diagnostic groups.

Safety and diagnostic yield of laparoscopically assisted full-thickness bowel biospy.

Advances in minimally invasive surgery have made laparoscopy and full-thickness bowel biopsy possible in the investigation of patients with suspected gastrointestinal neuromuscular disorders. The safety and diagnostic yield of this investigation have not been formally reported. A prospective study was undertaken of 124 patients with clinico-physiological diagnoses of chronic intestinal pseudo-obstruction, enteric dysmotility and severe irritable bowel syndrome undergoing LFTB in three European teaching centres with expertise in the management of gastrointestinal neuromuscular disorders.

Antitissue transglutaminase and antithyroid autoantibodies in children with Down syndrome and celiac disease.

Objectives: We measured circulating autoantibodies and evaluated the potential of circulating antitissue transglutaminase (tTG) antibodies to determine the presence of celiac disease (CD) in children with Down syndrome.

Methods: An ELISA based on recombinant human tTG was used to measure the levels of immunoglobulin A and immunoglobulin G antibodies in serum samples from 72 children with Down syndrome, 52 children with biopsy-verified CD, 21 disease controls with a normal small intestinal mucosa and 23 healthy controls. Of the 72 Down syndrome children, 11 under-went a small intestinal biopsy.

Full-thickness biopsy of the jejunum reveals inflammation and enteric neuropathy in irritable bowel syndrome.

Background & Aims: Irritable bowel syndrome (IBS) is regarded as a functional bowel disorder. Few studies have looked for histopathologic changes in the gut and only then in biopsy specimens from intestinal mucosa. Because bowel function is governed mainly by nerve plexuses in the bowel wall, we have investigated full-thickness bowel biopsy specimens in patients with severe IBS.

Effects of combined treatment with pravastatin and ursodeoxycholic acid on hepatic cholesterol metabolism.

Background: Treatment with ursodeoxycholic acid and also, to some degree, statins reduces cholesterol saturation of bile. The present study aimed [1] to study the effects of combined treatment with ursodeoxycholic acid and pravastatin on hepatic cholesterol metabolism and [2] to evaluate if the addition of pravastatin to ursodeoxycholic acid treatment has beneficial effects on the lipid composition of gallbladder bile in gallstone patients.

Materials And Methods: Nineteen patients with cholesterol gallstones were subjected to combined treatment with ursodeoxycholic acid (500 mg bid) and pravastatin (20 mg bid) for three weeks before cholecystectomy.

Outpatient laparoscopic cholecystectomy. A prospective study with 100 consecutive patients.

One hundred patients with cholelithiasis were included in a prospective consecutive follow-up study to evaluate laparoscopic cholecystectomy in a day surgical setting. The median operating time was 70 min. In 96% of the patients, it was possible to perform peroperative cholangiography.

Pool exercise combined with an education program for patients with fibromyalgia syndrome. A prospective, randomized study.

Objective: To evaluate the effects of 6 months of pool exercise combined with a 6 session education program for patients with fibromyalgia syndrome (FM).

Methods: The study population comprised 58 patients, randomized to a treatment or a control group. Patients were instructed to match the pool exercises to their threshold of pain and fatigue.

Introduction of herniorraphy with mesh plug and patch.

Objective: To evaluate the introduction of the Perfix mesh plug and patch system for inguinal hernia repair.

Design: Prospective consecutive follow-up study.

Setting: Teaching hospital, Sweden.

Reducing blood exposures during orthopedic surgical procedures.

Surgical team members constantly are exposed to blood during procedures. Inadvertent injuries (e.g.

Deoxycholic acid treatment in patients with cholesterol gallstones: failure to detect a suppression of cholesterol 7alpha-hydroxylase activity.

Unlabelled: Hillebrant C-G, Nyberg B, Angelin B, Axelson M, Björkhem I, Rudling M, Einarsson C (Huddinge University Hospital and Karolinska Hospital, Karolinska Institute, Stockholm, Sweden). Deoxycholic acid treatment in patients with cholesterol gallstones: failure to detect a suppression of cholesterol 7alpha-hydroxylase activity. J Intern Med 1999; 246: 399-407.