Publications by authors named "Nyarko K"

Background: Cervical cancer ranks as the fourth most common cancer among women, with 662,301 new cases and 348,874 deaths reported in 2022. The majority of the disease burden occurs in low- and middle-income countries. In Ghana, there were 3072 new cases and 1815 deaths reported in 2022.

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Access to safe sanitation facilities remains a critical public health concern, especially in rapidly urbanizing countries like Ghana. This study investigates the determinants of household toilet ownership among property owners in three urban districts in Ghana. Using a cross-sectional survey design, data were collected from 1,256 property owners selected through a multi-stage stratified sampling procedure.

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In 2015, Ghana launched the National Drinking Water Quality Management Framework (NDWQMF) to promote a risk-based approach to water quality through water safety plans (WSPs). This study uses a narrative review to synthesize WSP implementation progress in Ghana, identify gaps in practice, and provide recommendations for enhanced effectiveness and scale-up. Findings show limited uptake: only three of 88 urban water supply systems have adopted WSPs, while in the rural sector, the Community Water and Sanitation Agency has implemented WSPs in 177 of 1,022 small-town systems, and the safe water network in 46 systems.

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Disease surveillance remains important for early detection of new COVID-19 variants. For this purpose, the World Health Organization (WHO) recommends integrating of COVID-19 surveillance with other respiratory diseases. This requires knowledge of areas with elevated risk, which in developing countries is lacking from the routine analyses.

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The rise in honey production and imports into the United States necessitates the need for robust methods to authenticate honey origin and ensure consumer safety. This review addresses the scope of honey authentication, with a specific focus on the exploration of polyphenols and sugar markers to evaluate honeys in the U.S.

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Two billion people globally lack access to a basic toilet, and sanitation is a critical determinant of health and well-being. Evaluations of sanitation programmes typically measure disease or behaviour, and visual analogue scales (VASs) have not been used to measure users' feelings about their level of sanitation. In this study, we assess the validity of a horizontal sanitation VAS numbered 0-10, with end anchors 'best imaginable' and 'worst imaginable' sanitation.

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Background: The major burden of cervical cancer occurs in low- and middle-income countries. In Ghana, it is the second most common cancer among women. Infection with high-risk human papilloma virus (HPV) has been established as the cause of cervical cancer.

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Article Synopsis
  • The stromal microenvironment (SME) in breast cancer plays a crucial role in tumor behavior and response to treatment; its relationship with pre-diagnostic factors, especially in women of African ancestry, is not well understood.
  • A study analyzed 792 breast cancer patients to identify how pre-diagnostic host factors influenced SME characteristics using machine learning on tissue images, revealing that certain factors like parity and family history correlated with higher stromal cellular density.
  • The results suggest that epidemiological risk factors may impact tumor biology through changes in the SME, emphasizing the importance of considering these factors in breast cancer studies.
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Background: Urban sanitation challenges persist in Ghana, prompting Metropolitan, Municipal, and District Assemblies (MMDAs) to explore innovative funding mechanisms such as surcharges to fund sanitation services. This study assesses property owners' attitudes toward the imposition of sanitation surcharge for pro-poor sanitation improvement in the Kumasi Metropolis.

Method: An analytical cross-sectional study was conducted among 424 property owners in the Kumasi metropolis.

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α-Dicarbonyls are significant degradation products resulting from the Maillard reaction during food processing. Their presence in foods can indicate the extent of heat exposure, processing treatments, and storage conditions. Moreover, they may be useful in providing insights into the potential antibacterial and antioxidant activity of U.

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Open defecation continuously remains a major global sanitation challenge, contributing to an estimated 1.6 million deaths per year. Ghana ranks second in Africa for open defecation and had the fourth-lowest sanitation coverage in 2010.

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Epidemiologic data on insecticide exposures and breast cancer risk are inconclusive and mostly from high-income countries. Using data from 1071 invasive pathologically confirmed breast cancer cases and 2096 controls from the Ghana Breast Health Study conducted from 2013 to 2015, we investigated associations with mosquito control products to reduce the spread of mosquito-borne diseases, such as malaria. These mosquito control products were insecticide-treated nets, mosquito coils, repellent room sprays, and skin creams for personal protection against mosquitos.

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The presence of phenolic compounds in honey can serve as potential authenticity markers for honey's botanical or geographical origins. The composition and properties of honey can vary greatly depending on the floral and geographical origins. This study focuses on identifying the specific markers that can distinguish honey based on their geographical areas in the United States.

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The human fecal and oral microbiome may play a role in the etiology of breast cancer through modulation of endogenous estrogen metabolism. This study aimed to investigate associations of circulating estrogens and estrogen metabolites with the fecal and oral microbiome in postmenopausal African women. A total of 117 women with fecal (N = 110) and oral (N = 114) microbiome data measured by 16S rRNA gene sequencing, and estrogens and estrogen metabolites data measured by liquid chromatography tandem mass spectrometry were included.

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Off-grid hybrid power systems with renewable energy as the primary resource remain the best option to electrify rural/remote areas in developing countries to help attain universal electricity access by 2030. However, deploying these systems in West Africa faces several challenges and regularly fail to transition from pilot, donor-sponsored projects to sustainable large-scale implementations. The study examined the drivers and challenges by conducting a review of previous studies done in the region and a short survey in Ghana.

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Introduction: stillbirth is defined as a baby born with no signs of life. Globally, around 3.2 million stillbirths occur annually, of which, 98% are experienced in low and middle-income countries.

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Article Synopsis
  • The stromal microenvironment (SME) plays a significant role in tumor biology, impacting factors such as cancer aggressiveness and treatment response, particularly in women of African ancestry who suffer from severe breast cancer types.
  • A study involving 792 breast cancer patients in Ghana utilized machine-learning algorithms to analyze SME characteristics, revealing a connection between tumor-stroma ratio (TSR) and tumor-associated stromal cellular density (Ta-SCD) with tumor grades.
  • Findings indicated that lower TSR and higher Ta-SCD were linked to more aggressive tumors, with factors like parity and family history of breast cancer influencing Ta-SCD levels, while larger body sizes correlated with lower Ta-SCD.
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Article Synopsis
  • The study examines the outcomes of critically ill patients without COVID-19 admitted to ICUs during the pandemic compared to the previous year, highlighting a gap in understanding the pandemic's broader impact on non-COVID patients.
  • It revealed that all-cause in-hospital mortality increased during the pandemic (13.5% vs. 12.5%) along with higher rates of mortality in specific groups like patients with COPD exacerbations and recent immigrants.
  • The study utilized health data from Ontario and involved over 32,000 patients during the pandemic period, showing similarities in patient demographics but variations in health outcomes.*
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Introduction: Determining the high-risk human papillomavirus (HR-HPV) genotypes burden in women with and without cervical cancer afford a direct comparison of their relative distributions. This quest is fundamental to implementing a future population-based cervical cancer prevention strategy in Ghana. We estimated the cervical cancer risk by HPV genotypes, and the HPV vaccine-preventable proportion of cervical cancer diagnosed in Ghana.

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Background: The World Health Organization's case definition for influenza-like illness (ILI) includes a measured temperature of ≥38°C. We conducted this study to assess the effect of antipyretics on performance of ILI surveillance in Ghana.

Methods: A cross-sectional study was conducted in two districts of Ghana from September 2013 to May 2014.

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  • The study examines the link between the oral microbiome and breast cancer risk in Ghana, involving 881 women (369 with breast cancer, 93 with nonmalignant cases, and 419 controls).
  • The analysis showed that lower alpha-diversity (measured by different indices) in oral samples was associated with higher odds of breast cancer and nonmalignant breast disease.
  • Significant correlations were found between specific oral and fecal bacteria among breast cancer cases, particularly an inverse relationship between oral Porphyromonas and fecal Bacteroides.
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  • The study analyzed the impact of pathogenic variants (PVs) in breast cancer susceptibility genes on risk among Ghanaian women, finding significant associations in 871 breast cancer cases compared to 1,563 controls.
  • The frequency of PVs was notably higher in cases (8.38%) versus controls (1.22%), with substantial lifetime risk estimates for BRCA1, BRCA2, and PALB2 carriers, although these were lower than those seen in Western populations.
  • The results emphasize the importance of these findings for genetic counseling in West Africa, aiding localized risk assessment and informing medical practices.
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Background: Several anthropometric measures have been associated with hormone-related cancers, and it has been shown that estrogen metabolism in postmenopausal women plays an important role in these relationships. However, little is known about circulating estrogen levels in African women, and the relevance to breast cancer or breast cancer risk factors. To shed further light on the relationship of anthropometric factors and estrogen levels in African women, we examined whether measured body mass index (BMI), waist-to-hip ratio (WHR), height, and self-reported body size were associated with serum estrogens/estrogen metabolites in a cross-sectional analysis among postmenopausal population-based controls of the Ghana Breast Health Study.

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