Publications by authors named "Nyangoh Timoh Krystel"

Objective: To report our experience of outpatient periurethral injections of Bulkamid under local anesthesia in the office in female patients for stress urinary incontinence (SUI). Polyacrylamide hydrogel (Bulkamid) is a relatively recent bulking agent which may have a better safety profile than previous generations.

Methods: The data of all women who underwent outpatient periurethral Bulkamid injections under local anesthesia in the office at a single academic center were collected prospectively between November 2019 and August 2023.

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Introduction: The aims of this study were to describe survival outcomes in patients with ovarian cancer aged ≥80 years and to explore predictors of poor prognosis.

Methods: We collected clinical, demographic, histologic, surgical and follow-up data for patients with ovarian cancer aged ≥80 years from a multicenter French cohort (FRANCOGYN) who underwent surgery from 1999 to 2019. Primary endpoints were overall survival (OS) and disease-free survival (DFS).

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Purpose: This study sought to evaluate the biomechanical properties of the interface between the rotator cuff and the semicircular humeral ligament or rotator cable (RCa) using histological and biomechanical techniques.

Methods: Out of 13 eligible cadaver specimens, 5 cadaver shoulders with an intact rotator cuff were included, 8 were excluded due to an injured rotator cuff. The histological study enables us to describe the capsule-tendon interface between the infraspinatus tendon (IST) or supraspinatus tendon (SST) and RCa, and to detect loose connective tissue layers to determine their precise location and measure their length along the interface.

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Article Synopsis
  • MRKH syndrome is a serious condition that affects women's reproductive systems and can have other health issues, like kidney problems or heart defects.
  • Most women with MRKH have not been thoroughly checked for other related health problems, which is important for their treatment options.
  • Some women with MRKH may be able to get a uterine transplant, but many do not meet the criteria to be eligible for this procedure.
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  • Uterine innervation is crucial to female reproductive health and has significant implications for conditions like endometriosis; recent histological advances have revealed its complex structure and role in these disorders.
  • This review summarizes current research on uterine innervation, focusing on its effects on endometriosis and associated pain, using a systematic approach to analyze relevant studies.
  • The review identified 45 studies that highlighted a trend towards increased nerve fiber density in ectopic endometrial tissue, suggesting a link between this heightened innervation and the chronic pain seen in endometriosis patients.
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  • Pelvic gynecological surgeries often lead to complications due to damage to the autonomic nervous system, and recognizing the deep uterine vein (DUV) can help prevent this.
  • A systematic literature review and anatomical studies were conducted to better understand the DUV's structure and role in surgical settings, utilizing cadaver dissections and advanced imaging techniques.
  • The research confirmed the DUV's importance in dividing uterine regions and assisting surgeons in navigating the subperitoneal anatomy to reduce the risk of nerve and ureter injuries during procedures.
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  • The study aimed to evaluate different treatment options for women diagnosed with interstitial pregnancy (IP) by analyzing outcomes from various therapeutic methods between January 2008 and December 2019.
  • Three treatments were assessed: surgical treatment (ST), in situ methotrexate combined with systemic methotrexate (IS-MTX), and systemic methotrexate alone (IM-MTX). Success rates differed significantly, with ST showing a 100% success rate, while IS-MTX and IM-MTX had 70.6% and 31% success rates, respectively.
  • The findings suggest that ST and IS-MTX are effective for IP, while IM-MTX is less effective. Emergency surgery is recommended
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Objectives: The purpose of this study was to report the rate of stress urinary incontinence (SUI) recurrence after sling revision, and to determine predictive factors of SUI recurrence.

Methods: We conducted a retrospective cohort study in a single academic center between 2005 and 2022, of patients who underwent sling revision. Four surgical techniques were used for sling revision (loosening, section, partial, and total excision).

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Background: Annotated data are foundational to applications of supervised machine learning. However, there seems to be a lack of common language used in the field of surgical data science. The aim of this study is to review the process of annotation and semantics used in the creation of SPM for minimally invasive surgery videos.

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Article Synopsis
  • Hemostasis Hysterectomy (HH) is a rare but critical emergency procedure for post-partum hemorrhage, and all obstetrician-gynecologists should be prepared to perform it, despite limited training opportunities during residency.
  • A survey of French obstetrics and gynecology fellows revealed that only half had performed an HH during residency, with a majority having limited experience in scheduled hysterectomies.
  • The study concluded that lack of sufficient surgical exposure in residency hampers the development of competence in HH, highlighting a gap in training that needs to be addressed.
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Study Objective: To highlight the anatomical keys to safely performing an excision of deep endometriosis nodules of the sciatic nerve DESIGN: We present a didactic video combining an anatomical three-dimensional reconstruction of the pelvis using the Anatomage table and a surgical dissection video of the removal of deep endometriosis nodules of the left sciatic nerve [1]. The patient's approval was obtained. The patient consented that this surgical video be used for publication.

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  • The study focused on managing and understanding the survival rates of endometrial cancer patients aged 80 and older to identify indicators of poor prognosis.
  • Data was collected from a French cohort, revealing that 184 out of 1647 patients treated for endometrial cancer were senior citizens, with a median overall survival of 16.4 months.
  • Findings indicate that not using chemotherapy when indicated significantly correlated with worse survival outcomes, emphasizing the need for elderly patients to follow standard care guidelines for treatment.
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  • A chyle leak is a rare complication that can occur after surgery for breast cancer, specifically following procedures like a tumorectomy.
  • A case is presented involving a 78-year-old woman who experienced a chylous leakage after having sentinel lymph nodes removed during breast-conserving surgery for invasive ductal carcinoma.
  • After noticing a "milky" drainage fluid and swelling ten days post-surgery, she required a second surgery where a mass ligature was performed, and a drain was placed to manage the complication.
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Introduction: We set out to assess the compliance with a cesarean section color code protocol and its impact on maternal and neonatal outcomes since its implementation in our maternity ward.

Methods: This was a retrospective study including a sample of 200 patients per year who underwent a non-elective cesarean section delivery in Rennes University Hospital from January 1, 2015 to December 31, 2018. Patients were grouped by year and by color code (red, orange or green).

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Objective: To analyze outcomes and postoperative complications in patients undergoing robot-assisted isthmocele repair.

Method: This retrospective cohort study included 33 patients who had robot-assisted laparoscopic surgical management of an isthmocele between September 2013 and August 2020 in two French university hospitals. All charts were reviewed to identify patient characteristics, preoperative and postoperative anatomical findings, complications, and postoperative fertility and symptoms.

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Objective: To assess the surgical management and survival of severely obese patients with high-risk endometrial cancer.

Materials And Methods: Data from 269 patients with high-risk endometrial cancer who were treated between 2001 and 2018 were collected from a multicenter database (11 centers). We classified the patients according to their BMI and compared outcomes in two groups: a normal weight group of women with a BMI < 25 kg/m, and a severe obesity group of women with a BMI ≥ 35 kg/m.

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Article Synopsis
  • * Traditional treatments often involved invasive surgeries, but advancements in imaging now allow for earlier diagnosis and conservative management to help preserve the patient's fertility.
  • * The article focuses on a technique for delivering Methotrexate via vaginal injection under ultrasound guidance, which has shown promising results for treating non-tubal ectopic pregnancies.
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Background: The placement of posterior mesh during pelvic organ prolapse laparoscopic surgery has been incriminated as responsible for postoperative adverse outcomes such as digestive symptoms, chronic pelvic pain, and sexual dysfunction. These complications may be related to neural injuries that occur during the fixation of the posterior mesh on the levator ani muscle.

Objectives: The aim of our study was to describe the course of the autonomic nerves of the pararectal space and their anatomical relationship with the posterior mesh fixation zone on the levator ani muscle.

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  • Endometriosis is a chronic condition that negatively affects women's fertility, and the study aims to explore the relationship between preoperative Enzian scores and postoperative fertility outcomes after deep pelvic endometriosis surgery.
  • A retrospective study conducted at Rennes University Hospital analyzed data from women who underwent surgery for deep endometriosis, utilizing the ENDOREN database to assess the correlation between MRI-based Enzian scores and live birth rates.
  • Results showed a live birth rate of 35%, identifying the Enzian B score as a positive predictor for live births, while factors like uterine adenomyosis and previous endometriosis surgeries were found to negatively impact fertility outcomes.
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Non-tubal ectopic pregnancies represent fewer than 10% of all ectopic pregnancies. However, they are associated with a high rate of mortality due to late diagnosis and uterine horn rupture which requires radical emergency surgical management. Cornuectomy via laparoscopy is a treatment of choice.

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Schwannomas are benign nerve tumors arising mainly in the intracranial, cervical, or lumbar regions. We describe the case of a presacral schwannoma in a 42-year-old woman. This atypical localization is most often discovered by symptoms related to compression of nervous structures.

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Introduction And Hypothesis: Bladder outlet obstruction (BOO) is a common occurrence after midurethral sling (MUS) insertion and can result in acute or chronic urinary retention or de novo lower urinary tract symptoms (LUTS). However, the management of BOO after MUS is not standardised. The objective of this study was to compare two therapeutic strategies for suspected BOO after MUS.

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Article Synopsis
  • This study aimed to map the anatomy and function of nerve innervation in the human uterus to enhance understanding of pelvic pain conditions like endometriosis.* -
  • Researchers dissected female fetal pelvises to create a 3D reconstruction model, identifying nerve types and their distribution throughout different layers of the uterus.* -
  • The findings revealed diverse nerve fiber types and densities, highlighting rich innervation in certain areas, which could inform future therapeutic strategies for uterine pain disorders.*
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Uterine transplantation is on the rise worldwide. In contrast to its arterial anatomy, venous drainage of the uterus is poorly defined in the literature. Our aim was to provide a standardized description of uterine veins through a multimodal approach to establish anatomical landmarks for the uterine transplantation surgeon.

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