A planetary health perspective on the translation of climate change research into public health policy and practice: A scoping review protocol.

Background: Climate Change (CC) emanating from anthropocentric human activities is a great threat to the quality of human life and well-being worldwide. The translation of CC research evidence can play a critical role in promoting the formulation of climate-sensitive policies to equip public health systems for CC-associated disaster preparedness, response, and management. This scoping review seeks to explore knowledge translation approaches for promoting, the uptake, and use of CC research evidence in public health policy and practice.

Acquired Clinical Immunity to Malaria in Nonhuman Primates Coinfected with and Parasites.

Naturally acquired immunity to malaria develops over several years and can be compromised by concomitant infections. This study explored the influence of chronic schistosomiasis on clinical outcome and immunity to repeated malaria infection. Two groups of baboons ( = 8 each), were infected with Schistosoma mansoni cercariae to establish chronic infections.

Molecular characterization and antibiotic resistance profiles of isolated from fecal matter of domestic animals and animal products in Nairobi.

Background: has significant public health implications causing food borne and zoonotic diseases in humans. Treatment of infections due to is becoming difficult due to emergence of drug resistant strains. There is therefore need to characterize the circulating non-typhoidal (NTS) serovars in domestic animals and animal products in Kenya as well as determine their antibiotic resistance profiles.

Experimental phage therapy against haematogenous multi-drug resistant pneumonia in mice.

Background: Community-acquired haematogenous pneumonia is a rare infection, though it can be acquired nosocomially. Currently, antibiotics used against pneumonia have shown reduced efficacy. Thus, there is need for an alternative therapy against multidrug-resistant (MDRSA) strains in the community.

Safety, immunogenicity, and cross-species protection of a plasmid DNA encoding Plasmodium falciparum SERA5 polypeptide, microbial epitopes and chemokine genes in mice and olive baboons.

Incorporation of biomolecular epitopes to malarial antigens should be explored in the development of strain-transcending malarial vaccines. The present study sought to determine safety, immunogenicity and cross-species efficacy ofPlasmodium falciparum serine repeat antigen 5 polypeptide co-expressed with epitopes of Bacille-Calmette Guerin (BCG), tetanus toxoid (TT) and a chemokine gene. Olive baboons and BALB/c mice were randomly assigned into vaccine and control groups.

Efficacy of lytic Staphylococcus aureus bacteriophage against multidrug-resistant Staphylococcus aureus in mice.

Introduction: The use of bacteriophages as an alternative treatment method against multidrug-resistant bacteria has not been explored in Kenya. This study sought to determine the efficacy of environmentally obtained lytic bacteriophage against multidrug-resistant Staphylococcus aureus (MDRSA) bacterium in mice.

Methodology: Staphylococcus aureus bacterium and S.

Malaria endemicity and co-infection with tissue-dwelling parasites in Sub-Saharan Africa: a review.

Mechanisms and outcomes of host-parasite interactions during malaria co-infections with gastrointestinal helminths are reasonably understood. In contrast, very little is known about such mechanisms in cases of malaria co-infections with tissue-dwelling parasites. This is lack of knowledge is exacerbated by misdiagnosis, lack of pathognomonic clinical signs and the chronic nature of tissue-dwelling helminthic infections.

Parasite accumulation in placenta of non-immune baboons during Plasmodium knowlesi infection.

Background: Placental malaria (PM) causes adverse pregnancy outcomes in the mother and her foetus. It is difficult to study PM directly in humans due to ethical challenges. This study set out to bridge this gap by determining the outcome of PM in non-immune baboons in order to develop a non-human primate model for the disease.

Functional evaluation of malaria Pfs25 DNA vaccine by in vivo electroporation in olive baboons.

Plasmodium falciparum Pfs25 antigen, expressed on the surface of zygotes and ookinetes, is one of the leading targets for the development of a malaria transmission-blocking vaccine (TBV). Our laboratory has been evaluating DNA plasmid based Pfs25 vaccine in mice and non-human primates. Previously, we established that in vivo electroporation (EP) delivery is an effective method to improve the immunogenicity of DNA vaccine encoding Pfs25 in mice.