Investigation on the Interaction between Tetrakis (4-carboxylphenyl) Porphyrin and CopC by Spectroscopy and Docking Methods.

Background: Recently, the small molecule that inhibits the human copper-trafficking proteins Atox1 and CCS was reported, which suggested that small molecule has an effect on the copper regulation system in the cell. The copper chaperones CopC is regarded as a redox switch and possess barrel structure, thus the interaction between CopC and small molecules could give helpful information to elucidate the copper regulation mechanism. In addition, porphyrins play an important role in the metabolism of living body.