Proton magnetic resonance spectroscopy in mild cognitive impairment and Alzheimer's disease: a preliminary study.

Background: Mild cognitive impairment (MCI) is recognized as a transitional clinical state between normal aging and Alzheimer's disease (AD) and has significant higher rate of progression to AD.

Objective: To compare the changes of metabolites between AD and MCI in specific locations of the brain by using Magnetic Resonance Spectroscopy (MRS).

Material And Method: MMSE-Thai 2002 and neuropsychological test were performed in 17 patients with memory problem, classified into AD and MCI (10, 7 patients respectively).