A Stereocontrolled Synthesis of (+)-Febrifugine via Azide and Azide-Free Pathways.

(+)-Febrifugine, a natural antimalarial compound with a promising therapeutic profile, has become a hot target for synthetic chemists seeking to optimize its biological activity and expand its therapeutic applications. In this research, we present a stereocontrolled synthesis of (+)-febrifugine using both azide and azide-free approaches. Starting from the commercially available chiral pool precursor, d-glucose, the synthesis was completed in 20 steps for both approaches.

Partially Bio-Based Benzoxazine Monomers Derived from Thymol: Photoluminescent Properties, Polymerization Characteristics, Hydrophobic Coating Investigations, and Anticorrosion Studies.

In this work, four thymol-based benzoxazines were synthesized using four primary amines with different chain lengths, namely methylamine, ethylamine, 1-propylamine, and 1-butylamine, which are then named T-m, T-e, T-p, and T-b, respectively. The optical properties of the synthesized thymol-based benzoxazines were examined via the photoluminescent study of their solutions in acetone. The results show that all the prepared benzoxazines emitted blue light with the maximum wavelengths from 425 to 450 nm when irradiated by the excitation wavelengths from 275 to 315 nm.

Crystallographic and Spectroscopic Investigations on Oxidative Coordination in the Heteroleptic Mononuclear Complex of Cerium and Benzoxazine Dimer.

Among lanthanide-based compounds, cerium compounds exhibit a significant role in a variety of research fields due to their distinct tetravalency, high economic feasibility, and high stability of Ce(IV) complexes. Herein, a systematic investigation of crystallographic information, chemical properties, and mechanistic formation of the novel Ce(IV) complex synthesized from cerium(III) nitrate hexahydrate and 2,2'-(methylazanediyl)bis(methylene)bis(4-methylphenol) (MMD) ligand has been explored. According to the analysis of the crystallographic information, the obtained complex crystal consists of the Ce(IV) center coordinated with two nitrate ligands and two bidentate coordinated (-protonated and O,O-deprotonated) MMD ligands.

One-Pot Synthesis of Dibenzo[,]oxepines and Total Synthesis of Bauhinoxepin C.

In this work, we report a novel and simple one-pot synthesis of substituted dibenzo[,]oxepines under transition-metal-free conditions. This cascade process involves nucleophilic aromatic substitution followed by Knoevanagel condensation, as evidenced by the isolated reaction intermediates. We have also achieved the synthesis of anticancer bauhinoxepin C in 7 steps with 5.

A facile palladium catalysed 3-component cascade route to functionalised isoquinolinones and isoquinolines.

Palladium catalysed three component cascade process, involving coupling of 2-iodobenzoates, -benzaldehydes, or acetophenones with substituted allenes and ammonium tartrate as an ammonium surrogate, provides a novel and facile route to substituted functionalised isoquinolinones and isoquinolines in good yields.

Stereoselective Pd(0) catalysed five component cascade synthesis of complex Z,Z-bisallylamines.

Catalytic 5-component cascade chemistry provides an effective stereo- and regioselective route to novel multi-functional Z,Z-bisallylamines. The process, which is capable of considerable further extension, utilises ammonium tartrate as a novel ammonia source which avoids the use of ammonia gas or aqueous ammonia.