Long-term stability and bactericidal properties of galenic formulations of Cannabis sativa oils.

The long-term stability in real and accelerated time for galenic oils based on full-spectrum cannabis has been studied, using sesame oil as a dilutant. Sesame oil is one of the most used vehicles in the cannabis pharmaceutical industry due to the costs and increased oral bioavailability of cannabinoids. The real-time assays conducted at 25 °C over twelve months demonstrated high stability and showed no significant changes in the composition of cannabinoids, total polyphenols, flavonoids, or antioxidant capacity.

Anthelmintic Effect of Cannabidiol against .

Cystic echinococcosis is a global parasitic zoonosis caused by infection with the larval stage of . Cystic echinococcosis affects more than 1 million people worldwide, causing important economic costs in terms of management and livestock associated losses. Albendazole is the main drug used in treating human cystic echinococcosis.

Chemical profiles of cannabis sativa medicinal oil using different extraction and concentration methods.

The present study shows the variability in chemical profiles of three different varieties of extracts used in medicinal cannabis oil when using two different extraction and evaporation methods. Procedures were compared by analyzing rate of total terpenoids to the principal cannabinoids, tetrahydrocannabinol (THC) and cannabidiol (CBD), using gas chromatography coupled to mass spectrometry (GC-MS). The extraction of inflorescences using soxhlet method showed the highest mass of final extract.

Computer simulation of energy use, greenhouse gas emissions, and costs for alternative methods of processing fluid milk.

Computer simulation is a useful tool for benchmarking electrical and fuel energy consumption and water use in a fluid milk plant. In this study, a computer simulation model of the fluid milk process based on high temperature, short time (HTST) pasteurization was extended to include models for processes for shelf-stable milk and extended shelf-life milk that may help prevent the loss or waste of milk that leads to increases in the greenhouse gas (GHG) emissions for fluid milk. The models were for UHT processing, crossflow microfiltration (MF) without HTST pasteurization, crossflow MF followed by HTST pasteurization (MF/HTST), crossflow MF/HTST with partial homogenization, and pulsed electric field (PEF) processing, and were incorporated into the existing model for the fluid milk process.

Computer simulation of energy use, greenhouse gas emissions, and process economics of the fluid milk process.

Energy-savings measures have been implemented in fluid milk plants to lower energy costs and the energy-related carbon dioxide (CO2) emissions. Although these measures have resulted in reductions in steam, electricity, compressed air, and refrigeration use of up to 30%, a benchmarking framework is necessary to examine the implementation of process-specific measures that would lower energy use, costs, and CO2 emissions even further. In this study, using information provided by the dairy industry and equipment vendors, a customizable model of the fluid milk process was developed for use in process design software to benchmark the electrical and fuel energy consumption and CO2 emissions of current processes.

Invited review: Environmental impacts of dairy processing and products: a review.

The objective of this review is to summarize research efforts and case studies to date of the environmental impacts from dairy processing. The pervasiveness of greenhouse gas emission, water use, consumer waste, and other environmental impacts of dairy are described. An outline of the method of choice, the life cycle assessment, for conducting research and deciding appropriate allocation of the impacts is provided.

Mitigation of greenhouse gas emissions in the production of fluid milk.

Global climate change, driven by the buildup of greenhouse gas (GHG) emissions in the atmosphere, is challenging the dairy industries in the United States and throughout the world to develop sustainable initiatives to reduce their environmental impact. The U.S.

Good, clinical pain practice for pediatric procedure pain: metric considerations.

This paper is a brief primer in pediatric pain measurement.Two measurement instruments--the Faces, Legs, Activity, Cry and Consolability Scale and the Faces of Pain Scale-Revised--are presented along with their limitations.

Impact of hybrid delivery of education on student academic performance and the student experience.

Objectives: To compare student academic performance and the student experience in the first-year doctor of pharmacy (PharmD) program between the main and newly opened satellite campuses of the University of Maryland.

Methods: Student performance indicators including graded assessments, course averages, cumulative first-year grade point average (GPA), and introductory pharmacy practice experience (IPPE) evaluations were analyzed retrospectively. Student experience indicators were obtained via an online survey instrument and included involvement in student organizations; time-budgeting practices; and stress levels and their perceived effect on performance.

Good clinical pain practice for pediatric procedure pain: target considerations.

The objective of this review is to integrate current knowledge of pediatric procedure pain to develop a conceptual framework of good, clinical pediatric pain practice that can be used to improve the processes and outcomes of the clinical management of pediatric procedure pain in dentistry. This argues that targeting behavior confounds the assessment-intervention dynamic of pain management.

Good, clinical pain practice for pediatric procedure pain: iatrogenic considerations.

The primary objective of this review is to integrate current knowledge on pediatric procedure pain to develop a conceptual framework of good, clinical pediatric pain practice that can be used to improve the processes and outcomes of the clinical management of pediatric procedure pain in dentistry. This paper will review the manner in which iatrogenic factors influence the management of pediatric procedure pain.

Good, clinical pain practice for pediatric procedure pain: neurobiologic considerations.

The objective of this review is to integrate current knowledge of pediatric procedure pain to develop a conceptual framework of good, clinical pediatric pain practice that can be used to improve the processes and outcomes of the clinical management of pediatric procedure pain in dentistry. This paper will present four characteristics of pain neurobiology that critically influence clinical decisions in pediatric procedure pain management.

Measurement of sound power and absorption in reverberation chambers using energy density.

Reverberation chamber measurements typically rely upon spatially averaged squared pressure for the calculation of sound absorption, sound power, and other acoustic values. While a reverberation chamber can provide an approximately diffuse sound field, variations in sound pressure consistently produce uncertainty in measurement results. This paper explores the benefits of using total energy density or squared particle velocity magnitude (kinetic energy density) instead of squared pressure (potential energy density) for sound absorption and sound power measurements.

Reading problems, psychiatric disorders, and functional impairment from mid- to late adolescence.

Objective: To examine psychiatric morbidity and functional impairment of adolescents with and without poor reading skills during mid- to late adolescence.

Method: The sample consisted of 188 adolescents, 94 with poor reading skills and 94 with typical reading skills, screened from a larger sample in the public schools at age 15. To assess psychiatric disorders, participants were assessed annually with the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Epidemiologic Version (up to 4.

Circadian rhythm of core body temperature in subjects with chronic fatigue syndrome.

The pathophysiological basis for chronic fatigue syndrome (CFS) remains poorly understood. Certain symptoms of CFS, namely fatigue, neurocognitive symptoms and sleep disturbance, are similar to those of acute jet lag and shift work syndromes thus raising the possibility that CFS might be a condition associated with disturbances in endogenous circadian rhythms. In this study, we tested this hypothesis by examining the circadian rhythm of core body temperature (CBT) in CFS and control subjects.

Measuring faculty effort and contributions in medical education.

A national panel on medical education was appointed as a component of the AAMC's Mission-based Management Program and charged with developing a metrics system for measuring medical school faculty effort and contributions to a school's education mission. The panel first defined important variables to be considered in creating such a system: the education programs in which medical school faculty participate; the categories of education work that may be performed in each program (teaching, development of education products, administration and service, and scholarship in education); and the array of specific education activities that faculty could perform in each of these work areas. The panel based the system on a relative value scale, since this approach does not equate faculty performance solely to the time expended by a faculty member in pursuit of a specific activity.

Core body temperature is normal in chronic fatigue syndrome.

Background: Subjects with chronic fatigue syndrome (CFS) frequently report symptoms of subnormal body temperature and low-grade fever. We conducted a study to determine whether CFS subjects manifest any abnormality of core body temperature (CBT) that might help explain their fatigue.

Methods: Continuous 24-hour recordings of CBT measured every 5 min were performed in 7 subjects meeting the Centers for Disease Control definition of CFS.

Job retention and breast cancer: employee perspectives and implications for rehabilitation planning.

The article presents four case studies of employed women who have had breast cancer. Specifically, the authors examine respondents' career maintenance concerns in the areas of (a) worksite accessibility, (b) performance of essential job functions, (c) job mastery, and (d) job satisfaction. Post-employment strategies are presented to assist rehabilitation professionals in meeting the on-the-job needs of women with breast cancer.

Medicine and management: a combined educational program.

Rapidly evolving characteristics of our health care system are creating new and expanding opportunities for physician managers. Formal graduate degree training in management has become desirable to prepare the physician for these new professional responsibilities. The Schools of Medicine and Management at Northwestern University instituted a formal combined degree program eight years ago.