Antihyperglycemic activity of a novel polyherbal formula (HF344), a mixture of fifteen herb extracts, for the management of type 2 diabetes: Evidence from and studies.

Antihyperglycemic effects of a novel polyherbal formula (HF344), comprising fifteen Thai herbal extracts, were elucidated for pharmacological mechanisms and potential for managing type 2 diabetes mellitus, by employing , , and approaches. LC/MS analysis of HF344 extract revealed several phytoconstituents, with piperine identified as the major active compound. HF344 extract significantly enhanced insulin secretion in RINm5F cells and inhibited glucose uptake into the everted sacs of the mouse small intestine in a concentration-dependent manner compared to the control (p < 0.

The standardized , an Indonesian antidiabetic formulation, stimulating the glucose uptake and insulin secretion in the models.

is a polyherbal formulation commonly used for the traditional management of diabetes in Indonesia and is mainly prepared from (Burm.f.) Nees.

-Glucosidase Inhibitory Activity and Anti-Adipogenic Effect of Compounds from .

Chemical investigation of revealed 11 phenolic compounds, and the structures of these compounds were determined by analysis of their NMR and HR-ESI-MS data. All compounds were investigated for their -glucosidase inhibitory activity and anti-adipogenic properties. Phoyunnanin E () and phoyunnanin C () showed the most potent -glucosidase inhibition by comparing with acarbose, which was used as a positive control.

Three Novel Biphenanthrene Derivatives and a New Phenylpropanoid Ester from and Their -Glucosidase Inhibitory Activity.

A phytochemical investigation on the whole plants of revealed the presence of three new biphenanthrene derivatives named aerimultins A-C (-) and a new natural phenylpropanoid ester dihydrosinapyl dihydroferulate (), together with six known compounds (-). The structures of the new compounds were elucidated by analysis of their spectroscopic data. All of the isolates were evaluated for their -glucosidase inhibitory activity.

Four Novel Phenanthrene Derivatives with -Glucosidase Inhibitory Activity from .

Four new phenanthrene derivatives, gastrobellinols A-D (), were isolated from the methanolic extract of (Rchb.f.) Kuntze, along with eleven known phenolic compounds including agrostophyllin (), agrostophyllidin (), coniferyl aldehyde (), 4-hydroxybenzaldehyde (), agrostophyllone (), gigantol (), 4-(methoxylmethyl)phenol (), syringaldehyde (), 1-(4'-hydroxybenzyl)-imbricartin (), 6-methoxycoelonin (), and imbricatin ().

New Fluorene Derivatives from and Their -Glucosidase Inhibitory Activity.

Two new compounds, dihydrodengibsinin () and dendrogibsol (), were isolated from the whole plant of , together with seven known compounds (-). The structures of the new compounds were elucidated by their spectroscopic data. All these isolates were evaluated for their α-glucosidase inhibitory activities.

New Biflavonoids with α-Glucosidase and Pancreatic Lipase Inhibitory Activities from Boesenbergia rotunda.

Roots of (L.) Mansf. are prominent ingredients in the cuisine of several Asian countries, including Thailand, Malaysia, Indonesia, India, and China.

Oxyresveratrol: Structural Modification and Evaluation of Biological Activities.

Oxyresveratrol (2,4,3',5'-tetrahydroxystilbene, 1), a phytoalexin present in large amounts in the heartwood of Artocarpus lacucha Buch.-Ham., has been reported to possess a wide variety of biological activities.