Publications by authors named "Nurul Shielawati Mohamed Rosli"
Article Synopsis
- Angiostrongylus cantonensis is a type of nematode that causes eosinophilic meningitis in humans, and its genomic studies are crucial for developing diagnostics and treatments.
- The genome has been sequenced and analyzed, revealing it is approximately 260 Mb in size, with 17,280 scaffolds and various types of genes, including a high number of protein-coding genes and excretory-secretory proteins.
- The draft genome provides a resource for future research into the parasite and its associated diseases, helping to address unresolved scientific questions.
Between 10 and 25% of individuals with non-alcoholic fatty liver disease (NAFLD) develop hepatic fibrosis leading to cirrhosis and hepatocellular carcinoma (HCC). To investigate the molecular basis of disease progression, we performed a genome-wide analysis of copy number variation (CNV) in a total of 49 patients with NAFLD [10 simple steatosis and 39 non-alcoholic steatohepatitis (NASH)] and 49 matched controls using high-density comparative genomic hybridization (CGH) microarrays. A total of 11 CNVs were found to be unique to individuals with simple steatosis, whilst 22 were common between simple steatosis and NASH, and 224 were unique to NASH.
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