Clinical predictors of efavirenz-based regimen treatment durability: A two-year case-control study of antiretroviral-naïve patients.

Background: While efavirenz-associated adverse drug events (ADEs) were widely established, the clinical relevance is uncertain.

Objectives: We aimed to assess the extent of treatment interruption caused by efavirenz-associated ADEs.

Methods: A case-control study of efavirenz recipients who did, versus did not (control) develop adverse drug events (ADE), and who were matched for baseline CD4 + at a ratio of 1:1.