Chemical Composition of Artemisia Scoparia and Their Bioactivities.

Three undescribed sesquiterpenes (1-3), two enantiomeric pairs of monoterpenes (4a/4b-5a/5b), one alkyne (6), two known alkynes (7-8) and eight known coumarins (9-16) were isolated from the aerial parts extracts of Artemisia scoparia. The structures of these compounds were fully elucidated by their 1D and 2D NMR, HRESIMS spectral data analyses, and comparison with literature. The absolute configurations of compounds were determined by single-crystal X-ray crystallography (1), a comparison of experimental and calculated electronic circular dichroism (ECD) data (2-6).

Secondary metabolites produced by endophytic derived from roots of and their effect on melanin synthesis in murine B16 cells.

Five indole derivatives, 1-indol-7-ol (), tryptophol (), 3-indolepropionic acid (), tryptophan (), 3,3-di(1-indol-3-yl)propane-1,2-diol () and two diketopiperazines, cyclo(L-Pro-L-Tyr) (), cyclo[L-(4-hydroxyprolinyl)-L-leucine () along with one dihydrocinnamic acid () were isolated from VERA8, that endophytic bacteria derived from roots. This is a first report towards an isolation of endophytic strains (funji or bacteria) from the herb. The synergetic properties of the total extract compositions, as well as effects of the pure isolated secondary metabolites evaluated on their melanin synthesis in murine B16 cells towards for vitiligo treatment.

The chemical components of Nutt. and their antioxidant, antidiabetic and antibacterial activities.

Seventeen compounds were isolated from the capitula of Nutt. with various column chromatographic methods and semi-preparative HPLC. Their structures were identified by the spectroscopic data and comparison with literatures as 2'-hydroxy-4,4'-dimethoxy-chalcone; (), isoliquiritigenin (), eriodictyol (), naringenin (), maritimetin (), butin (), taxifolin (), luteolin (), 7,3',4'-trihydroxyflavone (), 8,3',4'-trihydroxyflavone-7---d-glucoside (), quercetin (), quercetagitin-7---d-glucoside (), quercetin-7---d-glucoside (), 3,4-dihydroxybenzoic acid (), caffeic acid (), coreoside B (), and -inositol ().

New coumarin from the roots of Prangos pabularia.

The new coumarin 1, yuganin A (7-methoxy-8-((1S,2S)-1,2,3-trihydroxy-3-methylbutyl)-2H-chromen-2-one) along with nine known coumarins, heraclenol 3'-O-β-D-glucopyranoside (2), oxypeucedanin hydrate 3'-O-β-D-glucopyranoside (3), heraclenol (4), oxypeucedanin hydrate (5), osthole (6), oxypeucedanin (7), heraclenin (8), isoimperatorin (9), imperatorin (10) and the disaccharide sucrose (11), have been isolated from the roots of Prangos pabularia, and the structures of these isolated compounds were elucidated by spectroscopic means, especially, UV, HR-ESIMS, and 1D and 2D NMR spectroscopy. Furthermore, the anti-melanogenic effect of yuganin A and its inhibitory effect on B16 cells were evaluated. Yuganin A may be useful in the treatment of hyperpigmentation and as a skin-whitening agent in the cosmetics industry.