Publications by authors named "Nuriye Ezgi Bektur Aykanat"
Cardiac hypertrophy caused by hyperthyroidism in rats: the role of ATF-6 and TRPC1 channels.
Can J Physiol Pharmacol
November 2021
Article Synopsis
- Hyperthyroidism can cause the heart to grow bigger, a condition called cardiac hypertrophy.
- Researchers studied rats to see how certain channels in cells (TRPCs) and stress in the cell's environment (ER stress) are involved in this heart problem.
- They discovered that specific proteins (ATF-6, IRE-1, and TRPC1) become more active in hyperthyroidism, which messes up calcium balance in the heart and leads to heart issues.
Article Synopsis
- Researchers studied a drug called anakinra to see how it helps with injuries in the intestines caused by a lack of blood flow and then a rush of blood back (this is called ischemia-reperfusion injury).
- They tested this on rats, dividing them into groups to compare the effects of different doses of anakinra.
- The results showed that anakinra reduced harmful signs of inflammation and preserved the intestine's structure better at a higher dose of 100 mg/kg.
Background/aim: Hyperthyroidism is associated with results in increased glomerular filtration rate as well as increased renin-angio- tensin-aldosterone activation. The disturbance of Ca2+ homeostasis in the endoplasmic reticulum (ER) is associated with many diseases, including diabetic nephropathy and hyperthyroidism. Transient receptor potential canonical 1 (TRPC1) channel is the first cloned TRPC family protein.
View Article and Find Full Text PDFNonalcoholic fatty liver disease (NAFLD) is an important health problem. The prevalence of NAFLD is increasing, especially in the Western countries. Although there are several intracellular pathways in NAFLD, endoplasmic reticulum (ER) stress has recently gained importance.
View Article and Find Full Text PDFAmong other cancers, prostate cancer is globally the second most rampant one with the incidence of 29.4% among men. SLIT2/ROBO1 signaling is very crucial pathway causally implicated in many cancers and reported to inhibit a variety of cancer cell types.
View Article and Find Full Text PDFAims: Diabetes is a common metabolic disease which damages many organs including the liver and causes endoplasmic reticulum (ER) stress, which originates from non-folded proteins. Sonic hedgehog (Shh) pathway plays a role in liver regeneration and repair. To our knowledge, there is no study showing the relation between ER stress and Shh pathway in the liver in diabetes.
View Article and Find Full Text PDFBackground: 14 million people are diagnosed with new cancer and approximately 8 million people die from cancer every year. Hepatocellular carcinoma is the most common type of liver cancer and covers almost 5-6% of cancer deaths worldwide. Silybum marianum, a plant that contains silymarin, has been used traditionally in the treatment of liver diseases for centuries.
View Article and Find Full Text PDF