Crystal structure, Hirshfeld surface analysis and DFT calculations of 7-bromo-2,3-di-hydro-pyrrolo[2,1-]quinazolin-9(1)-one.

The mol-ecular structure of the title compound, CHBrNO, is almost planar. The benzene and pyrimidine rings are essentially coplanar, with r.m.

Solvent-resistant microfluidic paper-based analytical device/spray mass spectrometry for quantitative analysis of C -ceramide biomarker.

We developed a highly efficient and low-cost organic solvents-resistant microfluidic paper-based analytical device (μPAD) coupled with paper spray mass spectrometry (PS-MS) for quantitative determination of C -ceramide as a prognostic biomarker for several diseases. Several models of μPAD patterns have been examined to select the most resistant and efficient microchannel barriers, which can provide continuous spray at ionization zone and prevent "coffee ring" effect. Moreover, the developed μPAD has enabled the analysis of low concentration of C -ceramide because of the maximum supply of deposited analyte through microchannel.