Publications by authors named "Nuriman Ozgunes"
We investigated vitamin D deficiency in pediatric sickle cell disease patients and its association with selected bone, lipid and inflammatory parameters. The study included 64 patients (33 SS and 31 SB) and 21 carriers (AS). Blood was obtained to assess levels of vitamin D, WBC, CRP, Ca, P, ALP, PTH, triglyceride, total cholesterol, LDL, VLDL, HDL, IL-2, IL-12, TNF-α, IL-4, IL-6, IL-10 and regulatory T cells.
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- Telomerase is an enzyme crucial for maintaining telomeres, often active in 90% of tumors but not in most normal cells.
- Imetelstat sodium (GRN163L) is a new telomerase inhibitor that shows promise in preclinical trials for reducing telomerase activity in cancer cells and is currently being tested in clinical trials for lung cancer treatment.
- GRN163L not only inhibits telomerase but also disrupts cell adhesion and alters the cytoskeleton in cancer cells, leading to halted proliferation and reduced metastasis, without relying on its telomerase activity.
Protein oxidation is defined as the covalent modification ofa protein, induced either directly by reactive oxygen species/reactive nitrogen species or indirectly by reaction with secondary by-products of oxidative stress. Protein carbonyls are the most commonly measured products of protein oxidation. Additionally, nitrotyrosine is a product of tyrosine nitration mediated by reactive nitrogen species such as peroxynitrite anion and nitrogen dioxide.
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