Does hyaluronidase injected in periocular area change skin ultrastructure?: Standardized in vitro analysis.

Background: Treatment with hyaluronic acid (HA) fillers as a strategy for rejuvenation has experienced a significant growth in recent years, accompanied by a parallel increase in its complications, the treatment of which, such as hyaluronidase, we must be aware of.

Patients/methods: 14 patients (28 eyes) had indication for upper blepharoplasty surgery in the Hospital Universitario y Politécnico La Fe. After surgery, periocular skin of one eye of each patient was infiltrated with 300 U of hyaluronidase (14 cases) while the skin of the fellow eye was preserved untreated (14 controls).

[Mesonephroid adenocarcinoma. Apropos of a new case and review of the literature].

Objectives: Mesonephric adenocarcinoma is a rare clinical entity, predominantly appearing in women, involved in great controversy about its histogenesis. Reported cases to date were not diagnosed in their initial stages and they were treated by radical surgery with poor results.

Methods: We report the case of a 71-year-old male with previous diagnosis of nephrogenic adenoma two years before.