Topical N-acetylcysteine for the treatment of lamellar ichthyosis: an improved formula.

Topical N-acetylcysteine is gaining recognition as a useful and safe therapy for lamellar ichthyosis. We report a case of inherited lamellar ichthyosis that showed a good response to treatment with a new formula of N-acetylcysteine cream. With this new formula, which is described in the article in a practical manner, the odor of sulfur was minimized and we obtained excellent adherence to treatment.

Reticular variant of mid-dermal elastolysis.

Mid-dermal elastolysis is a rare disorder characterised by focal loss of elastic tissue in the mid-dermis. Most patients present with lesions of fine wrinkling (type I) or perifollicular papules (type II). The reticular variant (type III) has been described less often in the literature.