Publications by authors named "Nuria Machin"

Article Synopsis
  • Platform trials enhance the efficiency and patient-centered approach of clinical research but face challenges in broader adoption due to lack of experience and planning tools.* -
  • The EU-PEARL initiative aims to improve platform trials through new methodologies, collaboration with patient representatives, and input from regulatory agencies.* -
  • Successful implementation of platform trials hinges on early engagement with stakeholders, particularly regulatory bodies and patients, to overcome obstacles in infrastructure and data sharing.*
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Background: Adolescents and young adults are among the most frequent Internet users, and accumulating evidence suggests that their Internet behaviors might affect their mental health. Internet use may impact mental health because certain Web-based content could be distressing. It is also possible that excessive use, regardless of content, produces negative consequences, such as neglect of protective offline activities.

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Systematic data on the risk of fatal and non-fatal injury from external causes to those who travel abroad for purposes of business or pleasure are seldom recorded and are consequently hard to come by. In this paper, the risk of fatal injuries to foreign travellers using historical and newly acquired data from national databases is estimated. Overall, it appears from these data that the risk of fatal injury to foreign travellers lies in the range of 20 to 90 per 100 000 person-years of exposure for many destinations worldwide, although different rates may pertain in selected situations where special conditions apply, for example, where there is heavy participation in risky sports or increased driving.

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