Publications by authors named "Nuria Lupion-Garcia"
Article Synopsis
- Post-transcriptional mechanisms play a vital role in maintaining progenitor cell identity and can be disrupted in cancer, particularly in acute myeloid leukemia (AML).
- Researchers used CRISPR screens to discover that regulators of P-bodies, which are cellular structures involved in RNA processing, are essential for the development and upkeep of AML.
- The study shows that while P-body loss minimally affects normal blood cell production, it significantly alters the behavior of leukemia cells by releasing tumor suppressor mRNAs, leading to changes in gene expression and potential new treatment strategies for myeloid leukemia.
Purpose: Cholangiocarcinoma (CCA) is usually diagnosed at advanced stages, with limited therapeutic options. Preclinical models focused on unresectable metastatic CCA are necessary to develop rational treatments. Pathogenic mutations in IDH1/2, ARID1A/B, BAP1, and BRCA1/2 have been identified in 30%-50% of patients with CCA.
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