Publications by authors named "Nuria Gonzalo-Diego"
Article Synopsis
- * A case study of a 72-year-old woman with renal cell carcinoma demonstrated significant drug interactions between everolimus and her other medications, carbamazepine and phenytoin, leading to initial underexposure to everolimus.
- * Therapeutic drug monitoring (TDM) played a key role in adjusting her dose of everolimus, successfully raising plasma levels from 3.7 ng/ml to 10.8 ng/ml, emphasizing the need for careful management of drug interactions to optimize treatment efficacy.
The anti-HER2 antibody trastuzumab have shown clinical activity in combination with chemotherapy in different breast cancer settings. However, most of patients treated with this antibody progress after a period of treatment. Activation of the kinase SRC has been linked with resistance to trastuzumab in several preclinical studies.
View Article and Find Full Text PDFDocetaxel is a semi-synthetic taxane with cytotoxic anti-neoplastic activity and, currently used as anticancer agent in several types of cancer. Docetaxel is highly bound to plasma proteins, and this significantly determines its clearance and activity. Therefore, measurement of free docetaxel in plasma is pharmacologically important when pharmacokinetics is investigated.
View Article and Find Full Text PDFBackground: The aim of this study was to evaluate the screening strategy (quantitative immunological test vs biochemical test) in a population-based screening program for colorectal cancer (CRC) in Catalonia.
Methods: The fourth round of a screening program for CRC with a fecal occult blood test was implemented in Hospitalet de Llobregat during 2008-2010. A biochemical test was offered to 50,227 individuals and a quantitative immunological test was offered to 12,707 individuals.