Publications by authors named "Nuria Fraile-Valcarcel"
Within-host transition to GES-55 during a GES-6-producing Serratia marcescens outbreak: Emergence of ceftazidime-avibactam resistance and increased susceptibility to carbapenems.
Sergio García-Fernández Jorge Rodríguez-Grande María Siller-Ruiz Nuria Fraile-Valcárcel Isabel Lara-Plaza
Int J Antimicrob Agents
August 2024
Article Synopsis
- The study tracks the emergence of resistance to ceftazidime-avibactam in a type of antibiotic-resistant bacteria (GES-type carbapenemases) during an unusual outbreak of Serratia marcescens in Spain during COVID-19.* ! -
- Researchers conducted a retrospective analysis using whole genome sequencing to understand the relationships between bacterial samples from patients and their environment, discovering a genetic connection and plasmid transfer related to resistance.* ! -
- Key findings include the appearance of a mutation that facilitated the development of resistance to ceftazidime-avibactam, highlighting the urgent need for improved diagnostic tools and better antimicrobial usage strategies to combat such outbreaks.* !
Two episodes of bacteremia of zoonotic origin caused by different Streptococcus canis isolates in the same patient within a time span of 1 year.
Domingo Fernández Vecilla Jorge Rodríguez Grande Nuria Fraile Valcárcel María Carmen Nieto Toboso Mikel Joseba Urrutikoetxea Gutiérrez
Eur J Clin Microbiol Infect Dis
February 2024
Two episodes of bacteremia of cutaneous origin in a female patient were caused by two unrelated Streptococcus canis isolates within 1-year interval between the two infection episodes. The most likelihood transmission route in both episodes was a dog pet that habitually licked patient´s legs. Isolates were characterised by antimicrobial susceptibility test and whole genome sequencing.
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