[Influence of adjuvants on the ability of anti-Tbp antibodies to block transferrin binding, iron uptake and growth of Neisseria meningitis].

Objective: To evaluate the effect of five adjuvants on the ability of specific anti-TbpA/B to block iron uptake in Neisseria meningitidis.

Materials And Methods: Transferrin binding complexes (TbpA/B) purified from a TbpB isotype II Neisseria meningitidis strain were used to obtain sera with five different adjuvant formulations in mice in order to test the effect of the adjuvant on the ability of specific anti-TbpA/B antibodies to block transferrin binding, iron uptake and growth by meningococci.

Results: Levels of anti-TbpA/B antibodies were relatively low (1:125 in most cases), the highest being obtained with the RAS adjuvant (1:3125).