Publications by authors named "Nuria Cano"
Article Synopsis
- The Latin American Dialysis and Renal Transplant Registry (RLADTR) was established in 1991 to gather data on renal replacement therapy (RRT) across 20 Latin American countries, highlighting yearly trends and patient statistics in 2010.
- The study reported a significant increase in end-stage renal disease (ESRD) prevalence from 119 to 660 patients per million from 1991 to 2010, with hemodialysis being the most common treatment option.
- The findings showed positive correlations between RRT prevalence and both gross national income (GNI) and life expectancy, while diabetes remained the leading cause of ESRD, and cardiovascular issues were the primary cause of death among patients.
Based on a medicinal-chemistry-guided approach, three novel series of druglike cycloalkyl-annelated pyrazoles were synthesized and display high affinity (pKi>8) for the sigma1 receptor. Structure-affinity relationships were established, and the different scaffolds were optimized with respect to sigma1 binding and selectivity versus the sigma2 receptor and the hERG channel, resulting in selective compounds that have Ki values (for sigma1) in the subnanomolar range. Selected compounds were screened for cytochrome P450 inhibition (CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP3A4), metabolic stability (rat and human liver microsomes), and cell-membrane permeability (Caco-2).
View Article and Find Full Text PDF