Publications by authors named "Nur Seda Gokdemir"
Introduction: Although the effect of adipose-derived mesenchymal stem cell exosomes (ADSC-exos) on wound healing with different doses are shown in various studies, efficient and sufficient doses of ADSC-exos are still unknown. The study aimed to determine the optimal dose of ADSC-exos in wound healing.
Methods: The 45 Sprague-Dawley rats were randomly divided into five groups, with seven animals in each.
Aim: The mental nerve, the extended part of the inferior alveolar nerve, is often injured during dentoalveolar, orthognathic, or tumor surgery. Numerous therapeutic interventions, including surgery and pharmacotherapy, have been used to enhance the recovery of nerve injuries. Dental pulp stem cells (DPSCs) represent an easily accessible source of adult stem cells that can be isolated from the pulp of extracted teeth.
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- This study focused on how TGF-B1-transfected adipose-derived mesenchymal stem cell (AD-MSC) conditional medium (TGF-B1-CM) affects CD44 expression and the behaviors of two breast cancer cell lines: MCF-7 and MDA-MB-231.
- The researchers treated these cell lines with different media and proteins, analyzing their effects on various biological activities such as cell proliferation, migration, and apoptosis using methods like Western blotting and the Muse Cell Analyzer.
- Results showed that TGF-B1-CM activated the smad signaling pathway, decreased CD44 expression, increased cell apoptosis, reduced proliferation, and hindered cell migration in
This is a single-center prospective, open-label, single arm interventional study to test the safety and efficacy of recently described ChipEXO™ for severe COVID-19 pneumonia. The ChipEXO™ is a natural product derived from convalescent human immune plasma of patients recovered from moderate COVID-19 infection. In September 2021, 13 patients with pending respiratory failure were treated with ChipEXO™ adapted for aerosolized formulation delivered jet nebulizer.
View Article and Find Full Text PDFRepair of Rat Calvarial Bone Defect by Using Exosomes of Umbilical Cord-Derived Mesenchymal Stromal Cells Embedded in Chitosan/Hydroxyapatite Scaffolds.
Int J Oral Maxillofac Implants
September 2022
Purpose: To seek out the bone regeneration effect of human umbilical cord-mesenchymal stem cell (hUC-MSC)-derived exosomes of loaded chitosan/hydroxyapatite (CS/HA) scaffold in a rat calvarium bone regeneration model.
Materials And Methods: The hUC-MSC exosomes were purified and characterized. The scaffolds were prepared by a freeze-drying method.
Efficacy of stem cell-based therapies for colistin-induced nephrotoxicity.
Environ Toxicol Pharmacol
August 2022
The increase in infections with multidrug resistant bacteria has forced to return to the use of colistin, antibiotic with known nephrotoxicity. Mesenchymal stem cells (MSCs) are being extensively investigated for their potential in regenerative medicine. This study aimed to investigate the possible protective mechanisms of the MSCs against kidney injury induced by colistin.
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- The COVID-19 pandemic accelerated the need for new treatments, leading to the exploration of convalescent plasma (CP) for passive immunity.
- The report focuses on a specific product called convalescent human immune plasma-derived exosome (ChipEXO), detailing its structural, biochemical, and biological evaluation.
- Results indicate that ChipEXO is both safe and effective in combating SARS-CoV-2 infections based on preclinical testing.