Potent halogenated xanthone derivatives: synthesis, molecular docking and study on antityrosinase activity.

Tyrosinase inhibitors can reduce melanin production for skin whitening, but some existing products may harm the skin. This study discovered six compounds that inhibit tyrosinase in the mushroom by over 50%. Compound displayed strong inhibition ( and for L-tyrosine and L-DOPA substrates, while compound showed high inhibition ( and ) for both substrates.