Publications by authors named "Nur Kubra Tasdemir"
Objectives: Juvenile Idiopathic Arthritis (JIA) is the most common rheumatic disease of childhood; the pathogenesis is associated with T cell activation. T cell activation can be counter-balanced by signals generated by inhibitory receptors (IRs) such as CTLA-4, PD-1, LAG-3, and TIM-3. Here, we identify the role of IRs in the pathogenesis of different JIA subtypes.
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- The study investigated the plasma levels and cell surface expression of TIM-3 and PD-1 checkpoint molecules in pediatric patients with chronic non-bacterial osteomyelitis (CNO).
- Researchers collected plasma samples from CNO patients during diagnosis and treatment and measured TIM-3 and PD-1 levels using specific assay techniques.
- Results showed lower plasma PD-1 levels in CNO patients compared to healthy controls, but no significant differences in cellular expression of TIM-3 and PD-1, suggesting T cell exhaustion may not be a significant factor in CNO and pointing to a need for further research.