Synthesis and evaluation of radiolabeled porphyrin derivatives for cancer diagnoses and their nonradioactive counterparts for photodynamic therapy.

Radioiodinated porphyrin derivatives and the corresponding nonradioactive iodine introduced compounds, [I]I-TPP ([I]3), [I]I-l-tyrosine-TPP ([I]9), I-TPP (3), and I-l-tyrosine-TPP (9) were designed, synthesized, and evaluated by and experiments. In cytotoxicity assays, 3 and 9 exhibited significant cytotoxicity under light conditions but did not show significant cytotoxicity without light irradiation. Biodistribution experiments with [I]3 and [I]9 showed similar distribution patterns with high retention in tumors.