Publications by authors named "Nur I Margyaningsih"
Article Synopsis
- Splenomegaly, or spleen enlargement, is commonly found in patients with malarial anemia caused by Plasmodium falciparum or P. vivax, but the reasons for this connection are not fully understood.
- A study in Papua, Indonesia measured red blood cell (RBC) concentrations in the spleens of 37 patients, discovering that spleen size correlated positively with the amount of red-pulp and negatively with white-pulp, indicating a relationship between spleen composition and size.
- The research revealed that retained RBCs, primarily uninfected, accounted for significant blood loss in P. falciparum infections, and this retention correlated negatively with hemoglobin levels and circulating RBC counts, highlighting the impact
Article Synopsis
- Streptococcus pneumoniae is a harmful bacterium causing severe infections, and there is limited research on the antibacterial effects of medicinal plants against it.
- This study investigates the antibacterial properties of 13 Indonesian medicinal plants, identifying Lawsonia inermis Linn. as the most effective against S. pneumoniae, with a minimum inhibitory concentration (MIC) of 0.16 mg/ml.
- The research also explores the mechanisms of action, revealing that L. inermis causes bacterial lysis, disrupts cell walls, and alters gene expression, particularly increasing lytA while decreasing peZA and peZT expression.
Background: A very large biomass of intact asexual-stage malaria parasites accumulates in the spleen of asymptomatic human individuals infected with Plasmodium vivax. The mechanisms underlying this intense tropism are not clear. We hypothesised that immature reticulocytes, in which P.
View Article and Find Full Text PDFBackground: Laparoscopic nephrectomy is a preferred technique for living kidney donation. However, positive-pressure pneumoperitoneum may have an unfavorable effect on the remaining kidney and other distant organs due to inflamed vascular endothelium and renal tubular cell injury in response to increased systemic inflammation. Early detection of vascular endothelial and renal tubular response is needed to prevent further kidney injury due to increased intraabdominal pressure induced by pneumoperitoneum.
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