Publications by authors named "Nur Akmalia Hidayati"
Article Synopsis
- Cancer therapy faces issues like drug resistance and severe side effects, prompting exploration of novel, cost-effective treatments like Piper nigrum (black pepper) extract as a complementary anticancer agent.
- Piper nigrum contains bioactive compounds such as piperine that show significant anticancer effects, including tumor inhibition and enhancing the effectiveness of traditional chemotherapy while reducing side effects.
- The review identifies challenges such as variability and bioavailability of PNE, underscoring the need for further research to validate its use in clinical settings and improve cancer treatment outcomes.
Bacterial cellulose nanocrystal as drug delivery system for overcoming the biological barrier of cyano-phycocyanin: a biomedical application of microbial product.
Heli Siti Halimatul Munawaroh Budiman Anwar Galuh Yuliani Intan Cahaya Murni Ni Putu Yunika Arindita Nur Akmalia Hidayati
Bioengineered
December 2023
Phycocyanin, produced by has been reported as an anti-inflammatory, anti-hyperalgesia, antioxidant, anti-tumor, and anti-cancer agent. However, the ingestion of phycocyanin in the body is often hindered by its instability against gastric pH conditions. The nano-drug delivery system has developed as a promising platform for efficient drug delivery and improvement as well as drug efficacy.
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- The study investigates a safer peptide-based ACE1 inhibitor derived from salmon skin collagen to treat COVID-19 in patients with comorbidities.
- In vitro methods confirmed the presence of key functional groups and showed ACE1 inhibition activity, with the highest inhibition at concentrations of 1000 and 2000 µg/mL while maintaining low cytotoxicity.
- In silico analysis indicated strong binding interactions between ACE1 and the collagen-derived peptides, suggesting they might be effective competitive inhibitors, outperforming the standard drug lisinopril.
Article Synopsis
- Fish skin collagen hydrolyzate shows strong potential as a DPP-IV inhibitor for treating type-2 diabetes, although its exact mechanism is still unknown.
- In silico methods were used to analyze peptides from tilapia skin collagen, confirming that hydrolyzed peptides exhibited better biological activity than the original collagen and were found to be non-toxic and non-allergenic.
- Docking simulations revealed several peptides had high binding affinities to DPP-IV, indicating that these peptides could be combined with existing antidiabetic drugs for enhanced insulin secretion in type-2 DM patients.
Article Synopsis
- Cyanobacteria like Spirulina platensis can absorb CO2 for photosynthesis and produce useful biomolecules, potentially reducing environmental pollution, especially when grown in wastewater.
- The study investigates how pigments from these cyanobacteria could serve as antidiabetic agents, using molecular docking to compare their effectiveness to commercial drugs like acarbose and linagliptin.
- Findings show that certain pigments (pheophytin, β-carotene, and phycocyanobilin) have promising binding affinities with key enzymes involved in diabetes management, suggesting their potential as competitive inhibitors and highlighting the need for further research in this area.