Dengue's climate conundrum: how vegetation and temperature shape mosquito populations and disease outbreaks.

Introduction: Dengue, a prevalent mosquito-borne viral disease in tropical regions, is influenced by environmental factors such as rainfall, temperature, and urbanization. This study aims to assess the effects of microclimate, vegetation, and Aedes species distribution on dengue transmission in distinct hotspot and non-hotspot locations.

Methods: This cohort study was conducted in two sites within Selangor, Malaysia: a recurrent dengue hotspot and a non-dengue hotspot.

Effectiveness of Lyoprotectants in Protein Stabilization During Lyophilization.

Proteins are commonly used in the healthcare industry to treat various health conditions, and most proteins are sensitive to physical and chemical changes. Lyophilization, also known as freeze-drying, involves sublimating water in the form of ice from a substance at low pressure, forming a freeze-dried powder that increases its shelf life. Extreme pressure and varying temperatures in the freeze-drying process may damage the protein's structural integrity.

Extracellular Vesicles in Ovarian Cancer: From Chemoresistance Mediators to Therapeutic Vectors.

Ovarian cancer (OC) remains the deadliest gynecological malignancy, with alarming projections indicating a 42% increase in new cases and a 51% rise in mortality by 2040. This review explores the challenges in OC treatment, focusing on chemoresistance mechanisms and the potential of extracellular vesicles (EVs) as drug delivery agents. Despite advancements in treatment strategies, including cytoreductive surgery, platinum-based chemotherapy, and targeted therapies, the high recurrence rate underscores the need for innovative approaches.

receptor gene mutation associated with catecholaminergic polymorphic ventricular tachycardia in children: a case report & literature review.

Background: Ryanodine receptor 2 () gene mutation causing catecholaminergic polymorphic ventricular tachycardia (CPVT) is one of the identified causes of sudden death in adults and children.

Case Description: We report a case of gene mutation presented with cardiac arrest and recurrent syncopal attack with accidental finding of cardiac tumour. For the systematic review, we used four databases (Scopus, PubMed, Ovid and Google Scholar) to search articles with the terms " gene mutation" and "catecholaminergic polymorphic ventricular tachycardia (CPVT)".

Use of a portable negative pressure wound therapy device on a hard-to-heal wound with exposed bone: a case study.

This case study examines the effectiveness of using negative pressure wound therapy (NPWT) in the management of a hard-to-heal (chronic) wound with exposed ankle bone to reduce associated wound exudate and promote production of granulation tissue. A 60-year-old male patient who was able to attend wound follow-up diligently twice weekly for eight weeks, and weekly thereafter, was selected from a private hospital to take part. During each dressing change, the wound was cleansed with superoxidised cleansing solution, and minimal sharp debridement was performed.

PAX7, a Key for Myogenesis Modulation in Muscular Dystrophies through Multiple Signaling Pathways: A Systematic Review.

Muscular dystrophy is a heterogenous group of hereditary muscle disorders caused by mutations in the genes responsible for muscle development, and is generally defined by a disastrous progression of muscle wasting and massive loss in muscle regeneration. is closely associated with myogenesis, which is governed by various signaling pathways throughout a lifetime and is frequently used as an indicator in muscle research. In this review, an extensive literature search adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines was performed to identify research that examined signaling pathways in living models, while quantifying expression in myogenesis.

Role of Olive Bioactive Compounds in Respiratory Diseases.

Respiratory diseases recently became the leading cause of death worldwide, due to the emergence of COVID-19. The pathogenesis of respiratory diseases is centred around inflammation and oxidative stress. Plant-based alongside synthetic drugs were considered as therapeutics due to their proven nutraceutical value.

Synthesis and Characterisation of Self-Cleaning TiO/PES Mixed Matrix Membranes in the Removal of Humic Acid.

Membrane application is widespread in water filtration to remove natural organic matter (NOM), especially humic acid. However, there is a significant concern in membrane filtration, which is fouling, which will cause a reduction in the membrane life span, a high energy requirement, and a loss in product quality. Therefore, the effect of a TiO/PES mixed matrix membrane on different concentrations of TiO photocatalyst and different durations of UV irradiation was studied in removing humic acid to determine the anti-fouling and self-cleaning effects.

The association between dengue case and climate: A systematic review and meta-analysis.

Although previous research frequently indicates that climate factors impact dengue transmission, the results are inconsistent. Therefore, this systematic review and meta-analysis highlights and address the complex global health problems towards the human-environment interface and the inter-relationship between these variables. For this purpose, four online electronic databases were searched to conduct a systematic assessment of published studies reporting the association between dengue cases and climate between 2010 and 2022.

Neuroprotective effect of phospholipase A from Malaysian venom against HO-induced cell damage and apoptosis.

Oxidative stress is one of the factors involved in the pathogenesis of several neurodegenerative diseases. It has been reported that a secretory phospholipase A known as A2-EPTX-NSm1a has lower cytotoxicity in neuronal cells compared to its crude venom. In this study, A2-EPTX-NSm1a was tested for its neuroprotective activity on human neuroblastoma cells (SH-SY5Y) differentiated into cholinergic neurons against oxidative stress induced by hydrogen peroxide (HO).

Bioreactor-grown exo- and endo-β-glucan from Malaysian : An and study for potential antidiabetic treatment.

This study aims to identify the roles of exo-β-glucan (EPS-BG) and endo-β-glucan (ENS-BG) extracted from (GL) in inhibiting the alpha-glucosidase enzyme, a target mechanism for postprandial hyperglycaemia regulation. Upscale production of GL was carried out using a 10 L bioreactor. The zebrafish embryo toxicity test (ZFET) was carried out based on OECD guidelines.

Qualitative exploration of Australian Muslim patients’ perceptions and experiences surrounding medication management during Ramadan.

Objective To explore Australian Muslim patients' perceptions and experiences surrounding medication management practices during Ramadan. Methods This was a qualitative exploration of the views and experiences of Muslim patients who were hospitalised during or shortly prior to Ramadan 2021. Data comprised comments obtained from a cross-sectional telephone or face-to-face questionnaire about medications and Ramadan fasting at a tertiary-referral hospital in Melbourne, Australia.

Knowledge, Readiness and Barriers of Street Food Hawkers to Support the Single-Use Plastic Reduction Program in Northeast Malaysia.

This study aimed to determine the knowledge, readiness, and barriers among street food hawkers to support the single-use plastic reduction program. A cross-sectional study was performed involving 440 night market food street hawkers from five districts in Kelantan, Malaysia selected through proportionate random sampling from 17 night market locations. The majority of the respondents had good knowledge level, 60% of respondents were ready to support this program, and 73% of them responded that barriers had low influence on them.

Dataset of physico-chemical water parameters, phytoplankton, flora and fauna in mangrove ecosystem at Sungai Kertih, Terengganu, Malaysia.

This data article presents the composition of selected physico-chemical water parameters, phytoplankton, flora and fauna in Sungai Kertih, Terengganu, Malaysia. Sungai Kertih is surrounded by mangrove forest and located nearby to a coastal hill namely Bukit Labohan that supports vast biological resources to its adjacent inhabitants. Therefore, a biodiversity and environmental assessment was conducted in Sungai Kertih from 19-21 August 2019 to document the biodiversity and physico-chemical water parameters of the river.

The Influence of Sociodemographic Factors on Mobile Device Use among Young Children in Putrajaya, Malaysia.

Technology is evolving rapidly around the world, and the use of mobile devices is increasing every day. Today, everyone owns a mobile device, including young children. Parents provide and allow young children to use mobile devices for various purposes.

Environment-friendly deoxygenation of non-edible Ceiba oil to liquid hydrocarbon biofuel: process parameters and optimization study.

Non-edible Ceiba oil has the potential to be a sustainable biofuel resource in tropical countries that can replace a portion of today's fossil fuels. Catalytic deoxygenation of the Ceiba oil (high O/C ratio) was conducted to produce hydrocarbon biofuel (high H/C ratio) over NiO-CaO/SiO-AlO catalyst with aims of high diesel selectivity and catalyst reusability. In the present study, response surface methodology (RSM) technique with Box-Behnken experimental designs (BBD) was used to evaluate and optimize liquid hydrocarbon yield by considering the following deoxygenation parameters: catalyst loading (1-9 wt.

Isolation and Characterization of A2-EPTX-Nsm1a, a Secretory Phospholipase A from Malaysian Spitting Cobra () Venom.

Phospholipase A (PLA) toxins are one of the main toxin families found in snake venom. PLA toxins are associated with various detrimental effects, including neurotoxicity, myotoxicity, hemostatic disturbances, nephrotoxicity, edema, and inflammation. Although venom contains substantial quantities of PLA components there is limited information on the function and activities of PLA toxins from the venom.

In vivo toxicity of bioreactor-grown biomass and exopolysaccharides from Malaysian tiger milk mushroom mycelium for potential future health applications.

Natural mycelial biomass (MB) and exopolysaccharides (EPS) of Malaysian tiger milk mushroom Lignosus rhinocerus are considered high-end components due to their high commercial potential value in drug discovery. This study aims to evaluate the toxicity of the mushroom extracts' generated in a bioreactor using the zebrafish embryo toxicity (ZFET) model assay as a new therapy for treating asthma. Both MB and EPS extracts, at concentrations 0.

Photoelectrical Dynamics Uplift in Perovskite Solar Cells by Atoms Thick 2D TiS Layer Passivation of TiO Nanograss Electron Transport Layer.

A deficiency in the photoelectrical dynamics at the interface due to the surface traps of the TiO electron transport layer (ETL) has been the critical factor for the inferiority of the power conversion efficiency (PCE) in the perovskite solar cells. Despite its excellent energy level alignment with most perovskite materials, its large density of surface defect as a result of sub lattice vacancies has been the critical hurdle for an efficient photovoltaic process in the device. Here, we report that atoms thick 2D TiS layer grown on the surface of a (001) faceted and single-crystalline TiO nanograss (NG) ETL have effectively passivated the defects, boosting the charge extractability, carrier mobility, external quantum efficiency, and the device stability.

Pellet diameter of in a repeated-batch fermentation for the trio total production of biomass-exopolysaccharide-endopolysaccharide and its anti-oral cancer beta-glucan response.

The pellet morphology and diameter range (DR) of were observed in a repeated-batch fermentation (RBF) for the trio total production of biomass, exopolysaccharide (EPS) and endopolysaccharide (ENS). Two factors were involved in RBF; broth replacement ratio (BRR: 60%, 75% and 90%) and broth replacement time point (BRTP: log, transition and stationary phase) in days. In RBF, 34.

Home-Initiated-Programme-to-Prepare-for-Operation: evaluating the effect of an animation video on peri-operative anxiety in children: A randomised controlled trial.

Background: Hospital admissions and surgical operations commonly trigger anxiety in young children. Despite employing numerous support measures in our hospital, such as a pre-operative play room, the encouragement of parental companionship during induction of anaesthesia and distraction therapy, allaying the anxiety of our young surgical patients remains a challenge.

Objectives: To evaluate the effectiveness of a Home-Initiated-Programme-to-Prepare-for-Operation (HIPPO) on emotional manifestation and anxiety in children undergoing surgery.

A two-dimensional crystal growth in anatase titania nanostructures driven by trigonal hydronium ions.

Two-dimensional growth or high-energy faceting during a wet-chemical nanocrystal growth involves a dynamic surfactant functionalization that selectively allows a particular crystal plane to grow and simultaneously, passivates others from evolving. Here, by simply controlling the concentration of hydronium ions in a liquid-phase deposition reaction, the two-dimensional growth of a few atoms thick and (001) facet in anatase titania nanostructures can be achieved. The morphology can be modified from nanocube to nanobelt and nanosheet by increasing the hydronium ion concentration.

Floral micromorphology and transcriptome analyses of a fragrant Vandaceous Orchid, Vanda Mimi Palmer, for its fragrance production sites.

Background: Vanda Mimi Palmer (VMP) is commercially valuable for its strong fragrance but little is known regarding the fragrance production and emission sites on the flowers.

Results: Olfactory perception detected fragrance only from the petals and sepals. Light and Environmental Scanning Electron microscopy analyses on fresh tissues showed distributions of stomata and trichomes concentrated mostly around the edges.

A rare case of unilateral postaxial duplicated foot in a developmentally normal child.

Diplopodia, being a rare congenital disorder, is infrequently discussed in published texts. Most reported cases have accounted the involvement of duplicated preaxial digits with other associated organ system and physical deformities. Here, we present an unusual case of isolated diplopodia involving postaxial toes in a child with no other organ and physical abnormalities.