[GPSM2 is highly expressed in gastric cancer to affect patient prognosis by promoting tumor cell proliferation].

Objectives: To explore the association between GPSM2 expression level and gastric cancer progression and analyze the functional pathways and action mechanism of GPSM2.

Methods: We analyzed GPSM2 expression levels in gastric cancer tumors based on data from the GEPIA database and the clinical data of 109 patients. Public databases enrichment analysis were used to assess the impact of GPSM2 expression level on survival outcomes and the functional pathways and action mechanism of GPSM2.

The rational design of europium complex based electrochemiluminescence sensor for highly efficient carbaryl detection.

To address the issue that most of the reported electrochemiluminescence (ECL) sensors are usually subjected to various complicated chemical modifications, we proposed a sensitive ECL sensor by using a neutral mononuclear lanthanide metal europium complex Eu(L) (L = 2-pyrazol-1-yl-6-(1H-tetrazol-5-yl)-pyridine) as luminophore with simple chemical composition for the accurate detection of carbaryl pesticide residues. The three conjugated tridentate pyrazo-pyridine- tetrazol ligands could put significant effect on the physical and chemical behavior of the central Eu ion, leading to the excellent luminescent performance of the Eu(L) complex enhanced by "antenna effect" of the auxiliary anionic organic ligands. The naphthol obtained from the hydrolysis reaction of carbaryl in an alkaline working solution could effectively and quantitatively quench the luminescence intensity of the Eu(L) complex, which has been theoretically confirmed by the detailed density functional theory (DFT) and time-dependent DFT (TDDFT) calculations, thus obviously strengthening the target detection capability on carbaryl.

Benzothiadiazole-Fused Cyanoindone: A Superior Building Block for Designing Ultra-Narrow Bandgap Electron Acceptor with Long-Range Ordered Stacking.

There are great demands of developing ultra-narrow bandgap electron acceptors for multifunctional electronic devices, particularly semi-transparent organic photovoltaics (OPVs) for building-integrated applications. However, current ultra-narrow bandgap materials applied in OPVs, primarily based on electron-rich cores, exhibit defects of high-lying energy levels and inferior performance. We herein proposed a novel strategy by designing the benzothiazole-fused cyanoindone (BTC) unit with ultra-strong electron-withdrawing ability as the terminal to synthesize the acceptor BTC-2.

[α-Cyperone Antagonizes Intestinal Mucosal Inflammatory Response Through Modulation of TLR4/NF-κB Signaling Pathway to Alleviate Crohn's Disease-Like Colitis in Mice].

Objective: To investigate the effect and potential mechanisms of α-cyperone (CYP) on Crohn's disease (CD) -like colitis induced by 2, 4, 6-trinitrobenzene sulfonic acid (TNBS) in mice.

Methods: The mice were randomly and evenly divided into wild type (WT), TNBS, CYP and 5-aminosalicylic acid (5-ASA) groups, with 10 mice in each group. The symptoms of enteritis, the function and structure of the intestinal barrier, and the expression levels of inflammatory factors, including interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and gamma-interferon (IFN-γ), in the colon were assessed.

Construction of electrochemical immunosensors based on Au@MXene and Au@CuS nanocomposites for sensitive detection of carcinoembryonic antigen.

Cancer is currently one of the major causes of human mortality and has received widespread attention. In this paper, Au@CuS composite nanomaterial as a sandwich immunosensor tag for carcinoembryonic antigen (CEA) detection strategy was studied. Herein, Au@CuS composite nanomaterials were obtained by Au nanoparticles modified with CuS, which were combined with secondary antibody (Ab) to construct an immunosensor that interacted with HO to produce a current response.

Impact of the combination of virtual reality and noninvasive brain stimulation on the upper limb motor function of stroke patients: a systematic review and meta-analysis.

Background: Stroke frequently results in upper limb motor dysfunction, with traditional therapies often failing to yield sufficient improvements. Emerging technologies such as virtual reality (VR) and noninvasive brain stimulation (NIBS) present promising new rehabilitation possibilities.

Objectives: This study systematically reviews and meta-analyses the effectiveness of VR and NIBS in improving upper limb motor function in stroke patients.

Superoxide dismutase positively regulates Cu/Zn toxicity tolerance in Sorghum bicolor by interacting with Cu chaperone for superoxide dismutase.

Heavy metal stress threatens plant growth and productivity. In this study, we investigated the effects of CuSO and ZnSO toxicity on sorghum seedlings, focusing on their impact on biomass, germination rates, growth parameters, antioxidant enzyme activities, gene expression profiles, and stress resistance mechanisms. As a result, eight sorghum superoxide dismutase (SOD) genes were identified, and their evolutionary relationships with cis-acting regulatory elements and their expressional patterns were evaluated.

The JNK/P38 signalling pathway activated by testin protects the intestinal epithelial barrier against Crohn's disease-like colitis.

The unknown mechanism that controls intestinal barrier dysfunction in individuals with Crohn's disease (CD) plays a crucial role in the onset of intestinal inflammation. Testin, an intercellular linker protein, has the potential to protect epithelial barrier function. This study aimed to analyse the effects of Testin on CD-like colitis and explore the possible underlying mechanism.

Self-Assembled Perylene Diimide (PDI) Nanowire Sensitized InO@MgInS S-Scheme Heterojunction as Photoelectrochemical Biosensing Platform for the Detection of CA15-3.

Inorganic/organic heterojunctions show promising applications as high-performance sensing platforms for photoelectrochemical (PEC) immunosensors. This work reports constructing a PEC biosensor for CA15-3 based on a self-assembled perylene diimide (PDI) nanowire sensitized InO@MgInS S-scheme heterojunction platform. P-type semiconductor CuO nanoparticles were designed as a signal burst source and were used as immunoassay labels.

A molecularly imprinting photoelectrochemical sensor based on BiOS-sensitized perovskite CsAgBiBr for sarcosine determination.

An original molecular imprinting photoelectrochemical (PEC) sensor for sarcosine detection based on stable lead-free inorganic halide double perovskite CsAgBiBr is proposed. CsAgBiBr as a lead-free halide perovskite material possesses several positive optoelectronic properties for PEC analysis, such as long-lived component to the charge-carrier lifetime, and strong absorption of visible light. At the same time, two-dimensional materials also offer excellent electronic and mechanical properties; thus, BiOS was used and combined with CsAgBiBr to provide a stable and large photocurrent, which also benefits from the  stability of perovskite CsAgBiBr.

Single-atom nanozymes: Emerging talent for sensitive detection of heavy metals.

In recent years, the increasingly severe pollution of heavy metals has posed a significant threat to the environment and human safety. Heavy metal ions are highly non-biodegradable, with a tendency to accumulate through biomagnification. Consequently, accurate detection of heavy metal ions is of paramount importance.

Highly Electroactive Co-Based Metal-Organic Frameworks as an Efficient Coreaction Accelerator for Amplifying Near-Infrared Electrochemiluminescence of Gold Nanoclusters in Biomarkers Immunoassay.

Metal nanoclusters (NCs) as a new kind of luminophore have acquired sufficient interest, but their widespread application is restricted on account of their relatively low electrochemiluminescence (ECL) efficiency. Then, aqueous metal NCs with high ECL efficiency were strongly anticipated, especially for the ultrasensitive analysis of biomarkers. Herein, a near-infrared (NIR) ECL biosensing strategy for the test of neuron-specific enolase (NSE) was proposed by utilizing -acetyl-l-cysteine (NAC)- and cysteamine (Cys)-stabilized gold NCs (NAC/Cys-AuNCs) as ECL emitters with the NIR ECL emission around 860 nm and a metal-organic framework/palladium nanocubes (ZIF-67/PdNCs) hybrid as the coreaction accelerator through their admirable electrocatalytic activity.

QTL mapping of downy mildew resistance in foxtail millet by SLAF‑seq and BSR-seq analysis.

Key message Three major QTLs for resistance to downy mildew were located within an 0.78 Mb interval on chromosome 8 in foxtail millet. Downy mildew, a disease caused by Sclerospora graminicola, is a serious problem that jeopardizes the yield and quality of foxtail millet.

A biocompatible surface display approach in Shewanella promotes current output efficiency.

The biology-material hybrid method for chemical-electricity conversion via microbial fuel cells (MFCs) has garnered significant attention in addressing global energy and environmental challenges. However, the efficiency of these systems remains unsatisfactory due to the complex manufacturing process and limited biocompatibility. To overcome these challenges, here, we developed a simple bio-inorganic hybrid system for bioelectricity generation in Shewanella oneidensis (S.

Magnolin inhibits intestinal epithelial cell apoptosis alleviating Crohn's disease-like colitis by suppressing the PI3K/AKT signalling pathway.

Background And Aims: Previous reports have shown that preventing excessive intestinal epithelial cell (IEC) apoptosis is a crucial approach for protecting the intestinal barrier in patients with Crohn's disease (CD). Magnolin (MGL) has various biological activities, including antiapoptotic activities, but its role in CD has largely not been determined. This study investigated how MGL impacts CD-like colitis and the underlying mechanism involved.

Development of reusable electrochemiluminescence sensing microchip for detection of vomitoxin.

In this work, a reusable DNA sensing microchip was developed for detection of vomitoxin (deoxynivalenol, DON) in sorghum using Cd-based core-shell CdSe@CdS quantum dots (QDs) as promising electrochemiluminescence (ECL) emitter. The size-adjustable aqueous phase CdSe@CdS QDs were prepared through homogeneous method, exhibiting strong cathodic ECL emission with a central wavelength of 520 nm in SO coreactant. And gold nanoparticles-modified iron cobalt cyanide hydrate (Fe-Co-Au) was introduced as an accelerator to amplify the ECL signal.

A signal polarity conversion photoelectrochemical immunosensor for neuron-specific enolase detection based on MgInS-sensitized CsPbBr.

A photoelectrochemical (PEC) immunosensor was designed based on MgInS-decorated inorganic halide perovskite CsPbBr combined with the signal polarity conversion strategy for neuron-specific enolase (NSE) detection. CsPbBr was applied as the basic photoactive material owing to its excellent optical and electronic properties, which provide a good PEC performance for sensor construction. In order to improve the stability of this perovskite, the three-dimensional flower-like MgInS with a desirable direct band gap was applied to enhance the PEC response.

Ternary electrochemiluminescence quenching effects of CuFeO@PDA-MB towards self-enhanced Ru(dcbpy) functionalized 2D metal-organic layer and application in carcinoembryonic antigen immunosensing.

Background: Carcinoembryonic antigen (CEA) is a significant glycosylated protein, and the unusual expression of CEA in human serum is used as a tumor marker in the clinical diagnosis of many cancers. Although scientists have reported many ways to detect CEA in recent years, such as electrochemistry, photoelectrochemistry, and fluorescence, their operation is complex and sensitivity is average. Therefore, finding a convenient method to accurately detect CEA is significance for the prevention of malignant tumors.

Bandgap-Regulated Electrochemiluminescence Enhancement Strategy for Florfenicol Detection Based on ZrCuO: A Multimodal Luminophore.

The low electrochemiluminescence (ECL) efficiency issue of zirconia (ZrO) has been a pressing problem since its discovery. In this study, a bandgap-regulated ECL enhancement strategy was developed to improve the ECL efficiency of ZrO. Specifically, through the calcination of metal-organic frameworks (MOFs), the MOF-derived bimetallic oxide ZrCuO was synthesized.

locus: bone related diseases and mouse models.

is a complex locus characterized by multiple transcripts and an imprinting effect. It orchestrates a variety of physiological processes via numerous signaling pathways. Human diseases associated with the gene encompass fibrous dysplasia (FD), Albright's Hereditary Osteodystrophy (AHO), parathyroid hormone(PTH) resistance, and Progressive Osseous Heteroplasia (POH), among others.

Nano-matrixes propped self-enhanced electrochemiluminescence biosensor for microRNA detection.

MicroRNAs (miRNA) are the potential biomarker for breast cancer, a biosensor for detecting miRNA-21 was successfully prepared by covalently linking carbohydrazide (CONH) and tris (4,4 '- dicarboxylic acid-2,2' - bipyridyl) ruthenium dichloride (Ru (dcbpy)) as a self-enhanced emitter (Ru-CONH). The biosensor was prepared by coating the electrode with mesoporous silica encapsulated Ru-CONH as luminophores (RMSNs) to covalently link a couple of DNA strands (Q1-H2). The RMSNs coated electrode exhibited strong ECL emission due to the intramolecular electron transfer between the electrochemically oxidized Ru (dcbpy) and co-reactant CONH.

A self-powered photoelectrochemical biosensing platform for H-FABP monitoring mediated by CsPbBr@COF-V.

Advanced bioelectronic detection based on the integration of modern optical electronics and biological systems has a broad prospect. The strategy of cathode signal amplification in self-powered photoelectrochemical (PEC) immunosensors with excellent performance is rarely reported in the field of immune analysis. Herein, the work demonstrates a self-powered PEC biosensor formed with BiOI photocathode and WO/SnS/ZnS photoanode, and CsPbBr@COF-V was used as the photocathode signal quenching source for the quantitative monitoring of heart fatty acid binding protein (H-FABP).