Publications by authors named "Nuo Wang"

Background: The use of highly active antiretroviral therapy has transformed AIDS into a chronic infectious disease, but issues of chronic inflammation and immune system activation persist. Modulating the gut microbiome of patients may improve this situation, yet the specific association mechanisms between HIV and the gut microbiome remain unclear. This study aims to explore the research hotspots and trends of the HIV and the gut microbiome, providing direction for future research.

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The demand for accurate, user-friendly, and sensitive at-home nucleic acid testing solutions is rising due to occasional outbreaks of various infectious diseases and a growing desire for an improved quality of life. In response, we developed the WeD-mini, a compact, palm-sized isothermal fluorescent diagnostic IoT device that weighs just 61 g. The WeD-mini features a uniquely designed, highly sensitive optical sensing system, ultra-low power consumption, a minimalist industrial design, and an intelligent operating algorithm.

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The rapid and accurate detection of viral infections is essential for effective disease management and prevention. Quantitative polymerase chain reaction (qPCR) remains the gold standard for viral detection due to its high sensitivity and specificity. However, its limitations-including the need for specialized equipment, trained personnel, and longer processing times-make it impractical for at-home or rapid testing.

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Background: Thermal ablation (TA), including radiofrequency ablation (RFA) and Microwave ablation (MWA) could reduce tumor burden and can stimulate an immune response, but it cannot maintain a lasting immune response. The alarming cytokine IL-33 is constitutively expressed by epithelial cells, endothelial cells, and fibroblasts, but is released during tissue injury to alert the immune system. The presence of ST2Tregs in TME may act as a barrier contributing to this phenomenon.

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Article Synopsis
  • * The study identified a 1327-bp region upstream of the MrBAS gene, revealing light-responsive elements and demonstrating that dark conditions reduce α-bisabolol levels in flowers.
  • * Transgenic tests showed that the MrBAS promoter can effectively drive gene expression specifically in flower tissues, indicating its potential for use in targeted genetic modification for crop improvement.
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Proteins have been studied and applied to improve the stability of anthocyanins (ACNs), but the changes in the pH microenvironment during the preparation of steady-state systems are often ignored, and more attention is given to the stability of the system after preparation. In this study, we propose the "anthocyanin front-end homeostasis strategy", which involves designing a system can protect anthocyanins under acidic conditions so that more anthocyanin prototypes can be loaded inside the protein. Anthocyanins are encapsulated in liposomes (Lip) at pH 3.

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The combination of food chemistry and computational simulation has brought many impacts to food research, moving from experimental chemistry to computer chemistry. This paper will systematically review in detail the important role played by computational simulations in the development of the molecular structure of food, mainly from the atomic, molecular, and multicomponent dimension. It will also discuss how different computational chemistry models can be constructed and analyzed to obtain reliable conclusions.

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The digestibility of ungelatinized, short-term retrograded and long-term retrograded starch from foxtail millet was investigated and correlated with starch chain length distributions (CLDs). Some variations in starch CLDs of different varieties were obtained. Huangjingu and Zhonggu 9 had higher average chain lengths of debranched starch and lower average chain length ratios of amylopectin and amylose than Dajinmiao and Jigu 168.

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Microbial secondary metabolites (SMs) and their derivatives have been widely used in medicine, agriculture, and energy. Growing needs for renewable energy and the challenges posed by antibiotic resistance, cancer, and pesticides emphasize the crucial hunt for new SMs. Anaerobic ammonium-oxidation (anammox) systems harbor many uncultured or underexplored bacteria, representing potential resources for discovering novel SMs.

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Tropospheric ozone (O) pollution can affect plant nutritional quality and secondary metabolites by altering plant biochemistry and physiology, which may lead to unpredictable effects on crop quality and resistance to pests and diseases. Here, we investigated the effects of O (ambient air, Am; ambient air +80 ppb of O, EO) on the quality compounds and chemical defenses of a widely cultivated tea variety in China ( 'Baiye 1 Hao') using open-top chamber (OTC). We found that elevated O increased the ratio of total polyphenols to free amino acids while decreasing the value of the catechin quality index, indicating a reduction in leaf quality for green tea.

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Aim: To explore the neuroprotective potential of hyperforin and elucidate its underlying molecular mechanisms involved in its therapeutic effects against vascular cognitive impairment (VCI).

Methods: The active compounds and possible targets of Hypericum perforatum L. that may be effective against VCI were found by network pharmacology in this research.

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Objective: To evaluate the correlation between the monocyte-to-high-density lipoprotein cholesterol ratio (MHR) and intracranial atherosclerotic stenosis-related emergent large vessel occlusion (ICAS-ELVO) in acute ischemic stroke patients with endovascular thrombectomy.

Methods: Included in this study were 215 patients who underwent endovascular thrombectomy. They were randomly assigned to training and testing datasets.

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Two emitters can be entangled by manipulating them through optical fields within a photonic cavity. However, maintaining entanglement for a long time is challenging due to the decoherence of the entangled qubits, primarily caused by cavity loss and atomic decay. Here, we found the entangled dark state between two emitters mediated by a dielectric cavity within epsilon-near-zero (ENZ) materials, ensuring entanglement maintenance over an extended period.

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Objectives: Elevation of the systemic immune inflammation (SII) index and system inflammation response index (SIRI) is known to be associated with higher risk of stroke and all-cause death. However, no study has reported their correlation with early neurological deterioration (END) following recombinant tissue-type plasminogen activator (IV-rtPA) in acute ischemic stroke patients. The aim of this study was to explore the correlation of SII and SIRI with the risk of END after IV-rtPA.

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Metrnl is a secreted protein involved in neurite outgrowth, insulin sensitivity, immunoinflammatory responses, blood lipids and endothelial protection. In this study, we investigated the role of Metrnl in ischemic stroke. Fifty-eight ischemic stroke patients (28 inpatient patients within 2 weeks of onset and 30 emergency patients within 24 h of onset) and 20 healthy controls were enrolled.

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Insect-induced plant volatile organic compounds (VOCs) may function as either direct defence molecules to deter insects or indirect defence signals to attract the natural enemies of the invading insects. Tea (Camellia sinensis L.), an important leaf-based beverage crop, is mainly infested by Ectropis obliqua which causes the most serious damage.

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Plastid ribosomal proteins play a crucial role in the growth and development of plants, mainly in the gene expression and translation of key genes in chloroplasts. While some information is known about the regulatory processes of plastid ribosomal proteins in various plant species, there is limited knowledge about the underlying mechanisms in rice. In this study, ethyl methanesulfonate (EMS) mutagenesis was used to generate a new mutant called wlp3 (white leaf and panicle3), characterized by white or albino leaves and panicles, which exhibited this phenotype from the second leaf stage until tillering.

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The dielectric resonances of spherically symmetric micro/nano cavity in zero-index materials have been systematically studied. However, the resonance properties of other shaped dielectric cavities in zero-index materials remain unclear. Here, we theoretically investigate the electromagnetic resonances of the dielectric cavity with cylindrical symmetry in the epsilon-near-zero materials.

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Background: COVID-19 (coronavirus disease 2019) pandemic has had enormous social and economic impacts so far. The nucleocapsid protein (N protein) is highly conserved and is a key antigenic marker for the diagnosis of early SARS-CoV-2 infection.

Results: In this study, the N protein was first captured by an aptamer (Aptamer 58) coupled to magnetic beads (MBs), which in turn were bound to another DNA sequence containing the aptamer (Aptamer 48-Initiator).

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Adsorbents play a vital role in responding to marine oil spills, yet effectively cleaning up viscous oil spills remains a technical challenge. Herein, we present a superhydrophobic oil-adsorbing felt prepared using melt-blown technology and functionally enhanced with a photoelectric composite CNT/PANI coating for effectively cleaning up high-viscosity oil spills. By virtue of its superior solar/Joule heating ability and thermally conductive fiber network, p-CNT/PANI@PP notably reduced crude oil viscosity and enhanced the oil diffusion coefficient within pores.

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Starch chain-length distributions play an important role in controlling cereal product texture and starch physicochemical properties. Cooked foxtail millet texture and starch physicochemical properties were investigated and correlated with starch chain-length distributions in eight foxtail millet varieties. The average chain lengths of amylopectin and amylose were in the range of DP 24-25 and DP 878-1128, respectively.

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Recently, scholars have been increasing concerned about microplastics (MPs). Unfortunately, information is lacking on the spatial distribution patterns of MPs in coastal seas; therefore, our understanding of the extent of offshore MP contamination remains incomplete. MP distribution in the seawater and surface sediments of an aquaculture area (AA), artificial reef area (AR), and comprehensive effect area (CEA) in Haizhou Bay were investigated in this study.

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Thyroid-associated ophthalmopathy (TAO) is the most common autoimmune inflammatory diseases of the orbit. The CD40-CD40L pathway has been regarded as a potential molecular mechanism contributing to the development and progression of TAO, and RNA aptamers with specific binding affinity to CD40 (CD40Apt) represents a promising inhibitor of the CD40-CD40L signaling in TAO treatment. In this study, CD40Apt was confirmed to specifically recognize mouse CD40-positive ortibtal fibroblast.

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Background: An association between Graves' disease (GD) and the gut microbiome has been identified, but the causal effect between them remains unclear.

Methods: Bidirectional two-sample Mendelian randomization (MR) analysis was used to detect the causal effect between GD and the gut microbiome. Gut microbiome data were derived from samples from a range of different ethnicities (18,340 samples) and data on GD were obtained from samples of Asian ethnicity (212,453 samples).

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The existence of interprovincial embodied carbon transfer not only makes it difficult to achieve carbon emission reductions but also exacerbates the inequity, inefficiency, and high costs of interprovincial carbon emission reduction rights and responsibilities. This paper uses multi-regional input-output analysis (MRIOA) to measure the interprovincial embodied carbon transfer in 2017, obtains the net carbon transfer between 30 provinces (municipalities and autonomous regions) and eight regions in 2017, and accounts for the interprovincial carbon compensation amount based on the carbon price in the national carbon market. This study finds that carbon transfer from economically developed provinces to less developed provinces still exists in China, and the overall distribution shows a spatial transfer pattern from south to north and from east to west, with the northwestern region bearing most of the carbon emission pressure for which it should receive corresponding financial compensation.

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