Tensor-conductance model for reducing the computational artifact in target tissue for low-frequency dosimetry.

In protecting human from low-frequency (<100 kHz) exposure, an induced electric field strength is used as a physical quantity for assessment. However, the computational assessment suffers from a staircasing error because of the approximation of curved boundary discretized with cubic voxels. The international guidelines consider an additional reduction factor of 3 when setting the limit of external field strength computed from the permissible induced electric field.

Effects of Rhein on Bile Acid Homeostasis in Rats.

Rhein, the active ingredient of rhubarb, a medicinal and edible plant, is widely used in clinical practice. However, the effects of repeated intake of rhein on liver function and bile acid metabolism are rarely reported. In this work, we investigated the alterations of 14 bile acids and hepatic transporters after rats were administered with rhein for 5 weeks.

Genome-wide transcriptional analysis of induced gastric carcinoma.

Kom (Aristolochiaceae) (AMK) is known for toxicity and mutagenicity. The tumorigenic role of AMK has yet to be understood. AMK extracts were extracted from root crude drug.

[Mechanism of nephrotoxicity of rhubarb in rats].

The aim of this study was to investigate the renal toxicity of rhubarb and its mechanism. The SD rats were randomly divided into three groups: normal group and two rhubarb extract groups (16, 2 g·kg⁻¹). According to the dose conversion method between human and animal, rhubarb 16 g·kg⁻¹ and 2 g·kg⁻¹ were equivalent to 10 times and 1.

Oral administration of Aristolochia manshuriensis Kom in rats induces tumors in multiple organs.

Ethnopharmacological Relevance: Aristolochia manshuriensis Kom (AMK), belonging to the Aristolochia family, is traditionally used in China to remove heart fire, promote dieresis, restore menstruation, and enhance milk secretion. The active constitutes of AMK are aristolochic acids (AAs, I and II) that are reported to cause serious side effects including nephrotoxicity and carcinogenicity.

Aim Of The Study: The tumorigenic role of AMK is far to be understood.

RhoA/ROCK Signaling Pathway Mediates Shuanghuanglian Injection-Induced Pseudo-allergic Reactions.

Shuanghuanglian injection (SHLI) is a famous Chinese medicine used as an intravenous preparation for the treatment of acute respiratory tract infections. In the recent years, the immediate hypersensitivity reactions induced by SHLI have attracted broad attention. However, the mechanism involved in these reactions has not yet been elucidated.

Oral chronic toxicity study of geniposide in rats.

Ethnopharmacological Relevance: Geniposide, the major active constituent of Fructus Gardeniae (FG), has been widely used to treat various diseases in China.

Aim Of The Study: This chronic toxicity study was conducted to investigate the safety of geniposide.

Materials And Methods: Geniposide was administered to Sprague-Dawley (SD) rats of both sexes by oral gavage at dosages of 25, 50, or 100mg/kg in a volume of 10mL/kg once daily for 26 weeks.