Rare Encounter: A Case Report of Hepatic Perivascular Epithelioid Cell Tumor - An Uncommon Mesenchymal Tumor in the Liver.

Introduction: Perivascular epithelioid cell tumor (PEComa) is a rare neoplastic mesenchymal tumor, more frequently found in the uterus, although it can occur in different organs. Hepatic PEComa is extremely rare, with only a few cases described in the literature.

Case Presentation: We present a case report of a 33-year-old female patient with a history of macroprolactinoma.

Liposome-Encapsulated Lysates to Reconstitute Intracellular Macromolecular Crowding Effects.

Intracellular macromolecular crowding impacts biomacromolecule behavior, including oligomerization, phase separation, and diffusion. However, understanding crowding effects in cells is challenging as cells respond and adapt to perturbations. Therefore, replicating in-cell crowding in liposomes would provide a good alternative to studying the consequences of macromolecular crowding.

From waste to resource: LIBS methodology development for rapid quality assessment of recycled wood.

Management and reuse of wood waste can be a challenging process due to the frequent presence of hazardous contaminants. Conventional detection methods are often limited by the need for excessive sample preparation and lengthy and expensive analysis. Laser-induced Breakdown Spectroscopy (LIBS) is a rapid and micro-destructive technique that can be a promising alternative, providing in-situ and real-time analysis, with minimal to no sample preparation required.

White matter alterations in episodic migraine without aura patients assessed with diffusion MRI: effect of free water correction.

Objective: To assess the effect of modeling free water (FW) on the identification of white matter (WM) microstructure alterations using diffusion Magnetic Resonance Imaging (dMRI) in episodic migraine without aura patients compared with healthy controls.

Background: Diffusion tensor imaging (DTI) studies examining WM in migraine patients previously overlooked the potential influence of FW partial volume effects. Correcting FW effects could offer a clearer understanding of WM changes in migraine.

Uncovering longitudinal changes in the brain functional connectome along the migraine cycle: a multilevel clinical connectome fingerprinting framework.

Background: Changes in large-scale brain networks have been reported in migraine patients, but it remains unclear how these manifest in the various phases of the migraine cycle. Case-control fMRI studies spanning the entire migraine cycle are lacking, precluding a complete assessment of brain functional connectivity in migraine. Such studies are essential for understanding the inherent changes in the brain of migraine patients as well as transient changes along the cycle.

Inhibition of tumour necrosis factor alpha by Etanercept attenuates Shiga toxin-induced brain pathology.

Infection with enterohemorrhagic E. coli (EHEC) causes severe changes in the brain leading to angiopathy, encephalopathy and microglial activation. In this study, we investigated the role of tumour necrosis factor alpha (TNF-α) for microglial activation and brain pathology using a preclinical mouse model of EHEC infection.

Bioelectronic osteosynthesis plate to monitor the fracture bone healing using electric capacitive variations.

Background: Bone fractures represent a global public health issue. Over the past few decades, a sustained increase in the number of incidents and prevalent cases have been reported, as well as in the years lived with disability. Current monitoring techniques predominantly rely on imaging methods, which can result in subjective assessments, and expose patients to unnecessary cumulative doses of radiation.

Enhancing spectral imaging with multi-condition image fusion.

Spectral Imaging techniques such as Laser-induced Breakdown Spectroscopy (LIBS) and Raman Spectroscopy (RS) enable the localized acquisition of spectral data, providing insights into the presence, quantity, and spatial distribution of chemical elements or molecules within a sample. This significantly expands the accessible information compared to conventional imaging approaches such as machine vision. However, despite its potential, spectral imaging also faces specific challenges depending on the limitations of the spectroscopy technique used, such as signal saturation, matrix interferences, fluorescence, or background emission.

Baclofen modulates the immune response after spinal cord injury with locomotor benefits.

Background And Purpose: Spinal cord injury (SCI) is a neurological condition that affects motor and sensory functions below the injury site. The consequences of SCI are devastating for the patients, and although significant efforts have been done in the last years, there is no effective therapy. Baclofen has emerged in the last few years as an interesting drug in the SCI field.

Wildfire ashes: evaluating threats on the Pantanal wetland reserve (Mato Grosso, Brazil) using ecotoxicological tests.

In 2020, the largest continuous wetland area on the planet, the Brazilian Pantanal, experienced an unprecedented fire that affected the entire ecosystem. Our goal was to elucidate the effects of ash presence following the fire events. We quantified the impact of ashes, collected in four Conservation Units, on soil, water, and atmosphere.

Unveiling the Potential of C Factor Applied to Pilot Bioavailability/Bioequivalence Studies-A Case Study with Pazopanib Drug Products.

When companies are uncertain about the potential of a new formulation to be bioequivalent to a Reference product, it is common practice to carry out downsized pilot studies as a gatekeeping in vivo strategy to decide whether to move forward or not with a full-size pivotal study. However, due to the small study size, these studies are inarguably more sensitive to variability. To address and mitigate the uncertainty of the conclusions of pilot studies concerning the maximum observed concentration (C), the factor was proposed as an alternative approach to the average bioequivalence statistical methodology.

Comparison between AI and human expert performance in acute pain assessment in sheep.

This study explores the question whether Artificial Intelligence (AI) can outperform human experts in animal pain recognition using sheep as a case study. It uses a dataset of N = 48 sheep undergoing surgery with video recordings taken before (no pain) and after (pain) surgery. Four veterinary experts used two types of pain scoring scales: the sheep facial expression scale (SFPES) and the Unesp-Botucatu composite behavioral scale (USAPS), which is the 'golden standard' in sheep pain assessment.

Digital Feedback Loop in Paraxial Fluids of Light: A Gate to New Phenomena in Analog Physical Simulations.

Easily accessible through tabletop experiments, paraxial fluids of light are emerging as promising platforms for the simulation and exploration of quantumlike phenomena. In particular, the analogy builds on a formal equivalence between the governing model for a Bose-Einstein condensate under the mean-field approximation and the model of laser propagation inside nonlinear optical media under the paraxial approximation. Yet, the fact that the role of time is played by the propagation distance in the analog system imposes strong bounds on the range of accessible phenomena due to the limited length of the nonlinear medium.

Anatomic Posterolateral Corner Reconstruction of the Knee Using Single Semitendinosus Autograft: Technical Note for the Borderline-length Graft.

The original LaPrade technique for anatomic reconstruction of the posterolateral corner of the knee uses two separate allografts. More recently, a modification of this technique, using an adjustable-length suspension device with a cortical button for tibial fixation, allows anatomic reconstruction with a single semitendinosus autograft. This modification is of utmost relevance when sources of allograft are not available for multiligament knee reconstruction.

Alterations of White Matter Microstructure in Migraine Patients Vary in the Peri-ictal Phases.

Alterations in white matter (WM) microstructure are commonly found in migraine patients. Here, we employ a longitudinal study of episodic migraine without aura using diffusion magnetic resonance imaging (dMRI) to investigate whether such WM microstructure alterations vary through the different phases of the pain cycle. Fourteen patients with episodic migraine without aura related with menstruation were scanned through four phases of their (spontaneous) migraine cycle (interictal, preictal, ictal, and postictal).

Novel sequence types and low levels of antimicrobial resistance associated with clinical mastitis in sheep flocks across Scotland.

This research paper aimed to demonstrate that mammary secretions provided by sheep farmers across Scotland from cases of clinical mastitis are free from environmental contamination, as well as to provide information on the major bacterial causes of disease and levels of antimicrobial resistance. Mastitis represents one of most significant diseases of small ruminant production worldwide. and coagulase-negative Staphylococcal species are common pathogens isolated from cases of sheep mastitis.

Improving LIBS-based mineral identification with Raman imaging and spectral knowledge distillation.

Combining data from different sensing modalities has been a promising research topic for building better and more reliable data-driven models. In particular, it is known that multimodal spectral imaging can improve the analytical capabilities of standalone spectroscopy techniques through fusion, hyphenation, or knowledge distillation techniques. In this manuscript, we focus on the latter, exploring how one can increase the performance of a Laser-induced Breakdown Spectroscopy system for mineral classification problems using additional spectral imaging techniques.

Lipid Priming of Adipose Mesenchymal Stromal Cells with Docosahexaenoic Acid: Impact on Cell Differentiation, Senescence and the Secretome Neuroregulatory Profile.

Background: Priming strategies that improve the functionality of MSCs may be required to address issues limiting successful clinical translation of MSC therapies. For conditions requiring high trophic support such as brain and spinal cord injuries, priming MSCs to produce higher levels of trophic factors may be instrumental to facilitate translation of current MSC therapies. We developed and tested a novel molecular priming paradigm using docosahexaenoic acid (DHA) to prime adipose tissue-derived mesenchymal stromal cells (ASCs) to enhance the secretome neuroregulatory potential.

Preserved working memory performance along with subcortical modulation during peri-ictal phases in spontaneous migraine attacks.

Objective: To analyze cognitive performance and brain activation during a working memory task in patients with migraine during various phases of the migraine cycle and compare to healthy participants.

Background: Cognitive difficulties reported during migraine attacks remain poorly understood, despite evidence that the lateral frontoparietal network undergoes reversible disturbances and decreased activation during attacks. Recent findings in resting state functional magnetic resonance imaging suggest that brain areas involved in this network interact with subcortical regions during spontaneous migraine attacks.

Design and Characterisation of a Novel Z-Shaped Inductor-Based Wireless Implantable Sensor for Surveillance of Abdominal Aortic Aneurysm Post-Endovascular Repair.

Purpose: An abdominal aortic aneurysm (AAA) is a dilation of the aorta over its normal diameter (> 3 cm). The minimally invasive treatment adopted uses a stent graft to be deployed into the aneurysm by a catheter to flow blood through it. However, this approach demands frequent monitoring using imaging modalities that involve radiation and contrast agents.