Synthesis, DFT, and biological evaluation of chalcone bearing pyrazoline ring against receptors.

Peptic ulcer disease (PUD), often caused by infection, is a prevalent gastrointestinal condition characterized by the erosion of the gastric or duodenal mucosal lining. adheres to gastric epithelial cells, secreting toxins and disrupting the stomach's defenses. relies on various receptors to establish infection, making these molecules attractive therapeutic targets.

Mesophase Behavior of Molecules Containing Three Benzene Rings Connected via Imines and Ester Linkages.

Ten new compounds based on the methineazo-azomethine (CH=N-N=CH) and ester linking groups were prepared and investigated for their mesophase behavior and optical stability, and liquid crystals of 4-substituted phenyl methineazo-azomethine phenyl 4-alkoxybenzoates, , were investigated. An alkoxy group with a length between 8 and 12 carbons is attached to the phenyl eater wing, while the other terminal ring is substituted in its 4-position with one of the polar NO, F, Cl, CHO, and N(CH) groups. The molecular structures of the newly prepared compounds were verified by using H NMR, C NMR, and elemental analysis.

Enhancing special education programs' curricula for students with intellectual disabilities in saudi arabia: A call for personalized approaches and inclusive practices.

Background/aims: In Saudi Arabia, students with intellectual disabilities (ID) receive some of their education through textbooks. However, using textbooks with students with ID contradicts the principles of providing services based on individuals with ID needs personalized plans to develop their individual abilities. This study aimed to investigate family and teacher perceptions of middle and high school curricula for students with ID in Saudi Arabia.

Correction: Targeting EGFR/PI3K/AKT/mTOR signaling in lung and colon cancers: synthesis, antitumor evaluation of new 1,2,4-oxdiazoles tethered 1,2,3-triazoles.

[This corrects the article DOI: 10.1039/D4RA02222J.].

Eco-synthesis route: Developing bis-hydrazono[1,2,4]-thiadiazoles via a green synthetic approach with calcium oxide-chitosan nanocomposite.

Modern environmental organic chemistry is focused on developing cost-efficient, versatile, environmentally acceptable catalytic chemicals that are also highly effective. Herein, hybrid calcium-chitosan nanocomposite films was prepared by doping calcium oxide molecules into a chitosan matrix at weight percentage (15, 20, and 25 % wt. chitosan‑calcium) using an easy and affordable simple co-precipitation process.

Targeting EGFR/PI3K/AKT/mTOR signaling in lung and colon cancers: synthesis, antitumor evaluation of new 1,2,4-oxdiazoles tethered 1,2,3-triazoles.

The EGFR/PI3K/Akt/mTOR pathway is important for metastasis, medication resistance, apoptosis prevention, and malignant transformation. Mutations in lung and colon cancer typically change this pathway's expression. As a result, a novel class of 1,2,4-oxdiazoles that are attached to 1,2,3-triazoles, 5-11, were created as possible anticancer drugs.

Osteoporosis as Perceived by Saudi Physicians: A Cross-Sectional Study of Quality of Practice and Current Barriers in Management.

Background Osteoporosis (OP) is a state of abnormal bone quality and architecture that leads to fragility fractures, with lifetime costs reaching 16.27 billion Saudi Arabian Riyal (SAR). Methods An electronic survey was distributed to physicians from July 2020 to May 2021 to assess the quality of the practice of physicians toward OP and barriers in OP management in Saudi Arabia.

Enhancement of the optical and electrical properties of poly ethyl methacrylate/polyvinyl chloride-zinc sulphide (PEMA/PVC@ZnS) ternary nanocomposite films.

Our research introduces a novel ternary nanocomposite consisting of polyethyl methacrylate/polyvinyl chloride-Zinc sulphide nanoparticles (PEMA/PVC@ZnS). Zinc sulphide (ZnS) nanoparticles were produced via a chemical method and then dispersed at different concentrations (0.02, 0.

The prevalence and pattern of complementary and alternative medicine use among cancer patients in a tertiary oncology center: a cross-sectional study.

Background: Complementary and alternative medicine (CAM) is widely used nationally and internationally for multiple medical conditions, including different stages of cancer. It is used by the patients for multiple purposes, including to cure diseases or resolve symptoms, as patients have the misconception that natural remedies are safer than radiotherapy and chemotherapy.

Objectives: The aim of this research is to investigate the prevalence, pattern, and purpose of CAM use by cancer patients at Princess Noorah Oncology Center (PNOC), King Abdulaziz Medical City, in Jeddah (KAMC-JD).

Laser energy partitioning in nanosecond pulsed laser-induced air breakdown: effect of incident laser energy.

Air breakdown is generated by a 1064 nm nanosecond pulsed laser beam, and laser energy deposited in the breakdown ( ), transmitted through the plasma region ( ) and carried away by the shock wave ( ) is estimated for the incident laser energy ( ) range of 60-273 mJ. The is approximately 85% of at 60 mJ, rapidly increasing to 92% at 102 mJ. The shock wave front velocity and radius are measured as a function of and propagation distance.

Fabrication, Structural Properties, and Electrical Characterization of Polymer Nanocomposite Materials for Dielectric Applications.

This research paper aims to fabricate flexible PVA/Cs/TiO nanocomposite films consisting of polyvinyl alcohol (PVA), chitosan (Cs), and titanium oxide (TiO) for application in energy storage devices. The samples were analyzed using X-ray diffraction (XRD), atomic force microscope (AFM), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), and energy dispersive X-ray (EDX) techniques. The impact of TiO on the electrical impedance, conductivity, permittivity, and energy efficiency of the PVA/Cs was determined in a frequency range of 100 Hz to 5 GHz.

Bioactive hybrid membrane-based cellulose acetate/bioactive glass/hydroxyapatite/carbon nanotubes nanocomposite for dental applications.

The present work aimed to fabricate a set of hybrid bioactive membrane in the form of bio-nanocomposite films for dental applications using the casting dissolution procedures. The formulation of the targeted materials was consisting of cellulose acetate/bioactive glass/hydroxyapatite/carbon nanotubes with a general abbreviation CA-HAP-BG-SWCNTs. The nanocomposites were characterized using XRD, FTIR, SEM-EDX and Raman spectroscopy.

Variational iteration method along with intelligent computing system for the radiated flow of electrically conductive viscous fluid through porous medium.

This article aims to investigate the analytical nature and approximate solution of the radiated flow of electrically conductive viscous fluid into a porous medium with slip effects (RFECVF). In order to build acceptable accurate solutions for RFECVF, this study presented an efficient Levenberg-Marquardt technique of artificial neural networks (LMT-ANNs) approach. One of its fastest back-propagation algorithms for nonlinear lowest latency is the LMT.

A design of neuro-computational approach for double-diffusive natural convection nanofluid flow.

The artificial intelligence based neural networking with Back Propagated Levenberg-Marquardt method (NN-BPLMM) is developed to explore the modeling of double-diffusive free convection nanofluid flow considering suction/injection, Brownian motion and thermophoresis effects past an inclined permeable sheet implanted in a porous medium. By applying suitable transformations, the PDEs presenting the proposed problem are transformed into ordinary ones. A reference dataset of NN-BPLMM is fabricated for multiple influential variants of the model representing scenarios by applying Lobatto III-A numerical technique.

Influence of Nanomaterials and Other Factors on Biohydrogen Production Rates in Microbial Electrolysis Cells-A Review.

Microbial Electrolysis Cells (MECs) are one of the bioreactors that have been used to produce bio-hydrogen by biological methods. The objective of this comprehensive review is to study the effects of MEC configuration (single-chamber and double-chamber), electrode materials (anode and cathode), substrates (sodium acetate, glucose, glycerol, domestic wastewater and industrial wastewater), pH, temperature, applied voltage and nanomaterials at maximum bio-hydrogen production rates (Bio-HPR). The obtained results were summarized based on the use of nanomaterials as electrodes, substrates, pH, temperature, applied voltage, Bio-HPR, columbic efficiency (CE) and cathode bio-hydrogen recovery (C Bio-HR).

Applications of Nanomaterials in Microbial Fuel Cells: A Review.

Microbial fuel cells (MFCs) are an environmentally friendly technology and a source of renewable energy. It is used to generate electrical energy from organic waste using bacteria, which is an effective technology in wastewater treatment. The anode and the cathode electrodes and proton exchange membranes (PEM) are important components affecting the performance and operation of MFC.

Silica-Based Bioactive Glasses and Their Applications in Hard Tissue Regeneration: A Review.

Regenerative medicine is a field that aims to influence and improvise the processes of tissue repair and restoration and to assist the body to heal and recover. In the field of hard tissue regeneration, bio-inert materials are being predominantly used, and there is a necessity to use bioactive materials that can help in better tissue-implant interactions and facilitate the healing and regeneration process. One such bioactive material that is being focused upon and studied extensively in the past few decades is bioactive glass (BG).

Optimization of the Electrochemical Performance of a Composite Polymer Electrolyte Based on PVA-KCO-SiO Composite.

Composite polymer electrolyte (CPE) based on polyvinyl alcohol (PVA) polymer, potassium carbonate (KCO) salt, and silica (SiO) filler was investigated and optimized in this study for improved ionic conductivity and potential window for use in electrochemical devices. Various quantities of SiO in wt.% were incorporated into PVA-KCO complex to prepare the CPEs.