Publications by authors named "Nufar Margalit"
Article Synopsis
- Coronary artery disease (CAD) is a major global health issue, and this study investigates the role of microRNA-483-5p in distinguishing between chronic CAD and acute myocardial infarction (MI) in male patients.
- Significant changes in miR-483-5p levels were observed, with higher concentrations in coronary arteries of acute MI patients compared to those with chronic CAD, while lower levels were found in the peripheral blood of both diseased groups compared to controls.
- The findings suggest that miR-483-5p could be a valuable biomarker and therapeutic target for understanding and treating cardiovascular diseases, due to its involvement in crucial processes like inflammation and tissue repair.
Article Synopsis
- The study focuses on the aortic valve (AV), which is the most commonly affected valve in heart diseases, aiming to identify specific microRNA (miRNA) molecules related to two types of valvular heart diseases: calcification and rheumatism.
- Researchers collected human aortic valves during surgery, extracted RNA, and conducted next-generation sequencing to discover different miRNA expressions, later validating the findings with a quantitative method.
- The results showed that certain miRNAs (miR-145-5p, miR-199a-5p, and miR-5701) had distinct expression levels between rheumatic and calcified AVs, providing significant evidence to better understand the mechanisms behind these heart conditions.
Article Synopsis
- - The study aims to investigate the levels of specific microRNAs (miRNAs) in the coronary sinus of heart failure (HF) patients during cardiac resynchronization therapy and compare them to miRNA levels in peripheral blood samples.
- - Researchers analyzed samples from 60 patients, identifying differences in levels of four specific miRNAs, finding that HF patients had higher levels of certain miRNAs in their peripheral blood compared to control subjects.
- - The findings suggest that changes in miRNA levels in the coronary sinus may provide more insight into heart failure mechanisms than traditional systemic blood analysis, highlighting the importance of localized cardiac assessments.
