Discovery, synthesis, and cytotoxic evaluation of isoquinolinequinones produced by derived from lichen.

Four isoquinolinequinones (1-4) were isolated from the fermentation broth of which were derived from lichens. Among them, mansouramycin H (1) was identified as a new isoquinolinequinone by comprehensive spectroscopic data analysis. The mansouramycins from presented broad cytotoxic activities, especially against MDA-MB-231, but the SAR and mechanism were still unclear.

Senkyunolide B exhibits broad-spectrum antifungal activity against plant and human pathogenic fungi via inhibiting spore germination and destroying the mature biofilm.

Background: Aspergillus infection seriously jeopardizes the health and safety of life of immunocompromised patients. The emergences of antifungal resistance highlight a demand to find new effective antifungal drugs. Angelica sinensis is a medicine-food herb and phthalides are its characteristic components.

Levistolide A ameliorates fibrosis in chronic kidney disease via modulating multitarget actions in vitro and in vivo.

Aims: The increasing incidence of chronic kidney disease (CKD) urgently calls for effective nephroprotective agents. Traditional Chinese Medicine Angelica sinensis and its formula are well known for CKD therapy, but the underlying mechanisms and effective substances of reno-protective effects remain unclear. To this end, we isolated eleven ligustilide dimers (1-11) from A.

Discovery, Preliminary Structure-Activity Relationship, and Evaluation of Oleanane-Type Saponins from for the Treatment of Ulcerative Colitis.

To discover ulcerative colitis (UC) treatment agents, 28 oleanane-type triterpenoid saponins (-) including three new saponins, pulsatillosides P-R (-), were isolated from . The isolated saponins could observably ameliorate UC by improving the intestinal epithelial cell barrier and intestinal flora . The structure-activity relationship indicated that the oligosaccharide chain at C-28 was essential for their anti-UC activities; the methyl group at the C-23 site of triterpene saponins showed important effects on anti-UC efficacy; the chain length of oligosaccharides at position C-28 had little effect on their anti-UC activities.

The Anti-inflammatory Effects of Isoflavonoids from Radix Astragali in Hepatoprotective Potential against LPS/D-gal-induced Acute Liver Injury.

Radix Astragali (RA) is an important Traditional Chinese Medicine widely used in the treatment of various diseases, such as pneumonia, atherosclerosis, diabetes, kidney and liver fibrosis. The role of isoflavonoids from RA in the treatment of liver injury remains unclear. The study aimed to explore hepatoprotective and anti-inflammatory effects of isoflavonoids from .

Amycolasporins and Dibenzoyls from Lichen-Associated and Their Antibacterial and Anti-inflammatory Activities.

Eleven metabolites, six echinosporins (-), four dibenzoyls (-), and an aromatic compound (), were isolated from the fermentation broth of lichen-associated . The structures of the new compounds (-, -) were elucidated by comprehensive spectroscopic analysis including data from experimental and calculated ECD spectra. Amycolasporins A-C () demonstrated antibacterial activities against , , and with MIC values of 25 or 100 μg/mL.

Effects of Periostracum Cicadae on Cytokines and Apoptosis Regulatory Proteins in an IgA Nephropathy Rat Model.

Periostracum cicadae, the cast-off shell of the cicada Fabricius, is used in traditional Chinese medicine for its diaphoretic, anticonvulsive, sedative, antipyretic, and antiallergic effects. However, the exact pathogenesis of immunoglobulin A nephropathy (IgAN) remains unclear, thereby hindering investigations to identify novel therapeutic agents. A rat IgAN model was established by administration of bovine serum albumin, lipopolysaccharide, and carbon tetrachloride, which simultaneously established blood stasis and a heat syndrome model.