Effect of doses on the bioavailability of phenytoin from a prompt-release and an extended-release preparation: single dose study.

Objective: To determine the effect of doses on the bioavailability of a prompt-release and an extended-release phenytoin capsule after given as single doses.

Material And Method: Eight healthy male volunteers were given single oral doses of 100, 200, and 300 mg of a prompt-release preparation (Ditoin) and an extended-release phenytoin (Dilantin Kapseals) preparation in a crossover design with a two weeks washout period after an overnight fast. Serial blood samples were collected over 72 h post-dose.

Bioequivalence study of generic acyclovir compared with the brand name acyclovir.

Unlabelled: The bioequivalence study of 200-mg generic acyclovir was conducted in healthy males. The reference Zovirax and the test Zevin were administered as a single oral dose after an overnight fast in a two-period, crossover design separated by 1 week. Serial blood samples were collected over a period of 24 hours.