Publications by authors named "Nubia de S Lobato"
Introduction: Excess weight during pregnancy is a condition that can affect both mother and fetus, through the maternal-fetal interface, which is constituted by the placenta and umbilical cord. The umbilical vein is responsible for transporting oxygen and nutrients to the fetus, and its proper functioning depends on the integrity of its structure. The remodeling of the umbilical vein represents one of the causes of inadequate transport of nutrients to the fetus, being potentially harmful.
View Article and Find Full Text PDFObesity, an important risk factor for cardiovascular disease, promotes vascular oxidative stress. Considering that free testosterone levels remain within the reference range, especially in obese young men and that testosterone stimulates reactive oxygen species (ROS) generation, we sought to investigate whether testosterone interferes with obesity-associated oxidative stress and vascular dysfunction in male mice. We hypothesized that testosterone favors ROS accumulation and vascular dysfunction in high fat diet (HFD)-fed obese mice.
View Article and Find Full Text PDFActivation of PI3K/Akt pathway mediated by estrogen receptors accounts for estrone-induced vascular activation of cGMP signaling.
Vascul Pharmacol
November 2018
Estrone (E1) produces remarkable vascular effects, including relaxation, modulation of proliferation, apoptosis and cell adhesion. This study investigated the role of estrogen receptors and endothelial signaling pathways in the vascular relaxation promoted by E1. Aortic rings from male Wistar rats (250-300 g) were contracted with phenylephrine and stimulated with graded concentrations of E1.
View Article and Find Full Text PDFArticle Synopsis
- Perivascular adipose tissue (PVAT) normally helps relax blood vessels, but this function is impaired in obesity and metabolic syndrome, potentially worsening vascular issues related to high body weight and blood sugar levels.
- The study explores the impact of a high-sugar diet on PVAT, specifically how it increases a protein modification known as β-N-acetylglucosamine (-GlcNAcylation), which is linked to reduced PVAT function.
- Findings from rat experiments indicate that a high-sugar diet leads to higher -GlcNAcylated proteins in PVAT, decreased nitric oxide production, and increased oxidative stress, which collectively contribute to vascular dysfunction.
Aims: The objective of this study was to analyze the influence of obesity and insulin resistance on tumor development and, in turn, the effect of insulin sensitizing agents.
Main Methods: Male offspring of Wistar rats received monosodium glutamate (400mg/kg) (obese) or saline (control) from the second to sixth day after birth. Sixteen-week-old control and obese rats received 5×10(5) Walker-256 tumor cells, subcutaneously injected into the right flank.