Correlations among visual analog scales, total nasal symptom scores, and peak nasal inspiratory flow in children with perennial allergic rhinitis.

Background: Visual analog scale (VAS) correlates well with total nasal symptom score (TNSS) but negatively correlates with peak nasal inspiratory flow (PNIF) in adults with allergic rhinitis (AR). Small children may not rate VAS properly and parents usually help assess their child's symptoms. Data on the correlations among parent-assessed VAS (P-VAS), VAS, TNSS, and PNIF in children with AR was limited.

Level of asthma control in children and adolescents before and during the COVID-19 pandemic.

Background: During the COVID-19 pandemic, national lockdowns were implemented worldwide. Asthma control was reported to have improved. However, some patients lost follow-up from the clinic because they intended to avoid crowds at the hospital.

Factor associated with food allergy among preschool children with atopic dermatitis, and resolution of atopic dermatitis.

Background: Food allergy (FA) has been reported in one-third of children with moderate-to-severe atopic dermatitis (AD).

Objective: To identify factor associated with food allergy among preschool children with AD, and to compare AD resolution between preschool children with and without FA.

Methods: A cross-sectional study using database registry and questionnaire interview was conducted at Siriraj Hospital(Bangkok, Thailand) during 2022, and physician-diagnosed AD children aged ≤ 6 years were enrolled.

Treatment Difficulties in Wheat Oral Immunotherapy and the Predictive Value of Wheat-Specific IgE.

Background: Factors associated with wheat oral immunotherapy (OIT) difficulties in patients with IgE-mediated wheat allergy have not been well studied.

Objective: We aimed to assess factors associated with difficulties in wheat OIT.

Methods: We retrospectively collected data from children under 18 years of age with history of IgE-mediated wheat allergy who underwent wheat OIT.

Identifying the stability of a new wheat gliadin extract by protein analysis, skin tests and cell degranulation assay.

Background: The commercial wheat extract for skin prick test (SPT) provides less sensitivity to predict wheat allergy, compared to in-house gliadin extracts. SPT is a preferred method to study extract stability as it is the aim of developing extract. The role of cell degranulation assay, a functional assay with the same mechanism as SPT, is not widely used to determine extract stability.

The natural history of childhood-onset nonallergic rhinitis; a long-term follow-up study.

Background: Non-allergic rhinitis (NAR) is characterized by symptoms of nasal inflammation without allergic sensitization. The long-term outcome of NAR in children is poorly defined.

Objective: To determine the natural history of childhood-onset NAR and the development of allergic rhinitis (AR) in these children.

Children with wheat anaphylaxis and with low wheat specific IgE have a different IgE immunoblot pattern than those with high wheat specific IgE.

Background: Children with wheat anaphylaxis can present with a wide range of wheat-specific IgE (sIgE).

Objective: To identify differences in clinical features and predominant wheat allergens sensitized by these patients.

Methods: Children with history of wheat anaphylaxis were recruited.

Defining Biomarkers to Predict Natural Resolution in Shrimp Allergy.

Purpose: Tolerance to shrimp has been reported in some patients with a history of shrimp allergy. The predictors of the natural resolution of shrimp allergy have not been widely explored. This study aimed to investigate the role of specific IgE (sIgE) and specific IgG4 (sIgG4) to shrimp extracts and the cross-reactive shrimp allergens tropomyosin (TM), arginine kinase (AK) and myosin light-chain (MLC), as markers of persistent or resolved shrimp allergy (PSA or RSA).

Prick and intradermal skin tests in patients with severe hymenoptera sting allergy using commercial versus in-house allergen extracts.

Background: Fire ant, honey bee, and wasp allergen extracts are useful in the diagnosis and treatment of severe Hymenoptera allergic patients.

Objective: To evaluate the result of skin prick test (SPT) and intradermal test (ID) compared between local and commercial insect allergen extracts in patients with severe Hymenoptera sting allergy.

Methods: SPT and ID using local and commercial insect allergen extracts were performed.

Exercise-food challenge test in patients with wheat-dependent exercise-induced anaphylaxis.

Background: Wheat-dependent exercise-induced anaphylaxis (WDEIA) is a severe and potentially life-threatening food allergy. Diagnosis of WDEIA is challenging because reactions are not always reproducible.

Objective: This study aimed to evaluate the positivity rate of exercise-food challenge test at our allergy unit in order to confirm the diagnosis, and to investigate the effect on the episode of reactions after the test.

Is mold sensitization associated with severe asthma exacerbation in children?

Background: Mold sensitization has been reported as a factor associated with severe asthma exacerbation (SAE).

Objective: To identify the factors associated with SAE in asthmatic children, particularly mold sensitization.

Methods: The asthmatic children recruited into this case-control study were classified into an SAE and an outpatient (OPD) group, based on their histories of asthma exacerbation with hospitalization in the preceding year.

Validation and Reliability of the Thai version of the Food Allergy Quality of Life Questionnaire-Parent Form (FAQLQ-PF).

Background: Food allergy has an impact on the quality of life of both patients and caregivers. It is, therefore, important to have a native language survey to evaluate health-related quality of life (HRQL) among food allergic children.

Objective: To translate the Food Allergy Quality of Life Questionnaire-Parent Form (FAQLQ-PF) to Thai language, and to validate this tool in Thai parents with food allergic children.

A potential role of gliadin extract skin prick test in IgE-mediated wheat allergy.

Background: Wheat extracts containing both water/salt and alcohol soluble proteins may increase extract's accuracy for diagnosing IgE-mediated wheat allergy.

Objective: This study aimed to determine the performance of new invented in-house prepared wheat extracts for skin prick test (SPT).

Methods: Children aged 1-18 years with history of immediate wheat allergy were recruited.

Prevalence of rat and mouse sensitization in Asian patients with respiratory allergy.

Background: Skin prick test (SPT) is useful in identifying rat and mouse sensitization.

Objective: To determine the prevalence of rat and mouse sensitization by using local and commercial allergen extracts.

Methods: Patients with allergic rhinitis or asthma were recruited.

Clinical and in vitro cross-reactivity of cereal grains in children with IgE-mediated wheat allergy.

Introduction And Objectives: Wheat and cereal grains have a broad range of cross-reactivity, but the clinical relevance of this cross-reactivity is uncertain. This study aimed to evaluate clinical and in vitro cross-reactivity with barley, oat, and Job's tears among wheat-allergic patients.

Materials And Methods: Patients aged 5 to 15 years with IgE-mediated wheat allergy were enrolled.

Characterization of children with IgE-mediated wheat allergy and risk factors that predict wheat anaphylaxis.

Background: The number of children presenting with IgE-mediated wheat reactions to academic medical centers in Thailand continues to increase.

Objective: Improved knowledge about the clinical characteristic of wheat allergy is urgently needed to better understand the risk factors and to improve proper treatment in this patient population.

Methods: A cross-sectional study using questionnaire review of children who presented with IgE-mediated wheat allergy during 2001 to 2015 was performed.

Clinical characteristics and outcomes of ocular allergy in Thai children.

Background: Allergic conjunctivitis (AC) is the most common ocular condition in allergic children. In tropical countries, the study about the clinical features and outcome of treatment is very limited.

Objective: To review clinical characteristics and outcomes of treatment in children with ocular allergy.

Food sensitization and food allergy in allergic Thai patients from a tertiary care center in Thailand.

Background: A skin prick test (SPT) and food challenge test (OFC) are useful in identification of food sensitization and food allergy.

Objective: To evaluate food allergen sensitization by SPT and food allergy by OFC in allergic Thai patients.

Methods: SPTs for common food allergens were performed on allergic patients at Siriraj Hospital, Bangkok, Thailand, from 2011 to 2015.

Carrying rates of epinephrine devices in children with food-induced anaphylaxis.

Background: Carrying epinephrine can save lives in patients with anaphylaxis. The feature of epinephrine in prefilled syringe that commonly prescribed in Thailand may influence the willingness to carry. However, the rates of carrying prefilled syringe epinephrine are unknown in children with history of food-induced anaphylaxis.

Natural resolution of non-anaphylactic shrimp allergy in patients diagnosed 10 years earlier by oral food challenge.

Background: Shrimp allergy is considered a lifelong condition. The natural resolution of shrimp allergy is not well studied.

Objective: To investigate the natural resolution of shrimp allergy among a cohort of patients diagnosed with shrimp allergy 10 years earlier by oral shrimp challenge.

Medication used to control symptoms of chronic urticaria in children.

Background: A number of guidelines for management of CU were established based on evidences in adults. In children, the response to CU treatment was not widely studied.

Objective: To investigate the medications used to control symptoms of CU in children and to identify factors associated with time to control CU.

Disseminated cryptococcosis in two boys with novel mutation of CD40 Ligand-Associated X-linked hyper-IgM syndrome.

X-linked hyper-IgM syndrome (XHIM) caused by CD40L mutations is a primary immunodeficiency condition that increases susceptibility to opportunistic infections. Disseminated cryptococcosis in XHIM is rarely reported in children. Here, we report two related boys who have a novel hemizygous frameshift c.

Accuracy of in-house alcohol-dissolved wheat extract for diagnosing IgE-mediated wheat allergy.

Background: The standard method for diagnosing immediate wheat allergy is oral food challenge test (OFC). However, OFC can provoke anaphylaxis during the challenge process. Skin prick test (SPT) using commercial wheat extract yielded unsatisfactory result for diagnosis of wheat allergy.