Publications by authors named "Nu Yao"

The molecular basis for the propensity of a small number of environmental proteins to provoke allergic responses is largely unknown. Herein, we report that mite group 13 allergens of the fatty acid-binding protein (FABP) family are sensed by an evolutionarily conserved acute-phase protein, serum amyloid A1 (SAA1), that promotes pulmonary type 2 immunity. Mechanistically, SAA1 interacted directly with allergenic mite FABPs (Der p 13 and Blo t 13).

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Article Synopsis
  • - Our study aimed to create a test (NanoVelcro CTC-RNA assay) to analyze RNA from circulating tumor cells (CTCs) in metastatic castration-resistant prostate cancer (mCRPC) patients to predict their sensitivity to androgen receptor signaling inhibitors (ARSIs).
  • - We focused on a specific cancer subtype (PCS1) known for its severity and resistance to ARSIs, using advanced technologies for cell purification and RNA analysis, and rigorously validated our approach with prostate cancer cell lines.
  • - Testing on patient blood samples showed our assay can identify the PCS1 subtype accurately, with higher scores linked to ARSI resistance, confirming its potential to guide treatment decisions for mCRPC patients.
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Aberrant type 2 responses underlie the pathologies in allergic diseases like asthma, yet, our understanding of the mechanisms that drive them remains limited. Recent evidence suggests that dysregulated innate immune factors can perpetuate asthma pathogenesis. In susceptible individuals, allergen exposure triggers the activation of complement, a major arm of innate immunity, leading to the aberrant generation of the C3a anaphylatoxin.

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Professor Donald Coffey and his laboratory pioneered studies showing the relationships between nuclear shape and cellular function. In doing so, he and his students established the field of nuclear morphometry in prostate cancer. By using perioperative tissues via biopsies and surgical sampling, Dr.

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The key factors underlying the development of allergic diseases-the propensity for a minority of individuals to develop dysfunctional responses to harmless environmental molecules-remain undefined. We report a pathway of immune counter-regulation that suppresses the development of aeroallergy and shrimp-induced anaphylaxis. In mice, signaling through epithelially expressed dectin-1 suppresses the development of type 2 immune responses through inhibition of interleukin-33 (IL-33) secretion and the subsequent recruitment of IL-13-producing innate lymphoid cells.

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High levels of the intermediate filament keratin 17 (K17) correlate with a poor prognosis for several types of epithelial tumors. However, the causal relationship and underlying mechanisms remain undefined. A recent study suggested that K17 promotes skin tumorigenesis by fostering a specific type of inflammation.

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