Publications by authors named "Ntilara Touzlatzi"
Aims: COVID-19 is associated with diabetic ketoacidosis (DKA), hyperglycaemic hyperosmolar state (HHS) and euglycaemic DKA (EDKA); however, evidence regarding parameters affecting outcome and mortality rates is scarce.
Methods: A systematic literature review was conducted using EMBASE, PubMed/Medline, and Google Scholar from January 2020 to 7 January 2021 to identify all studies describing clinical profile, outcome and mortality rates regarding DKA, HHS, DKA/HHS and EDKA cases in COVID-19 patients. The appropriate Joanna Briggs Institute tools were used for quality assessment; quality of evidence was approached using GRADE.
Article Synopsis
- The study explores the potential of sodium nitroprusside (SNP) as a treatment for anxiety in schizophrenia, highlighting its inconsistent effects in animal models.
- It was found that a single low dose of SNP can reduce anxiety-like behavior in rats, while higher doses may depress activity levels without altering anxiety response.
- Repeated doses of SNP did not impact anxiety or activity in rats, indicating that its effects are sensitive to the dosing, timing, and treatment schedule.
Rationale: Experimental evidence indicates that the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist ketamine impairs cognition and can mimic certain aspects of positive and negative symptoms of schizophrenia in rodents. Nitric oxide (NO) is considered as an intracellular messenger in the brain, and its abnormalities have been linked to schizophrenia.
Objectives: The present study was designed to investigate the ability of the NO donor sodium nitroprusside (SNP) to counteract schizophrenia-like behavioural deficits produced by ketamine in rats.